Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. It is a clinically heterogeneous disorder especially in terms of disease severity. Current investigations suggest that genes and gene-gene interactions not only influence on susceptibility to MS but also affect the disease severity. In this study, we investigated the contribution of the HLADRB1*1501 ...

BACKGROUND Diabetes mellitus is one of the most common endocrine disorders accompanied with many metabolic syndromes. Use of herbal medicines has always been an option to treat a great number of diseases such as diabetes and its complications. In this study the liver-protective effects of hydroalcoholic extract of Allium hirtifolium on liver enzymes level in rats with alloxan-induced diabetes m...

shallot (allium altissimum regel.) is a medicinal, industrial and perennial plant that has underground tubers. it is one of the most important allium species in iran, which normally grows in semi-cold to very cold highlands. because of being a wild plant, shallot is encounter with water deficit during its growth season. therefore evaluation of water requirement of shallot is important. in order...

Dear Editor, I read the original article by Keshvari et al. published in the previous issue of the Iranian Red Crescent Medical Journal with interest. 1 At first, the large number of samples (367 samples) was impressive. Although, sampling and genotyping performance of such large-scale specimen need many hours, the obtained results could reflect a clear view of distribution of HCV genotypes amo...

BACKGROUND Haptoglobin (Hp) polymorphisms have been suggested to be associated with many pathological conditions, including cardiovascular diseases, infectious diseases, and type 2 diabetes. For the first time, we aimed to investigate the possible association between Hp genotypes and metabolic syndrome (MES) in a sample of Iranian subjects. METHODS In this study, 291 patients with MES accordi...

BACKGROUND Endometriosis influenced by both genetic and environmental factors. Associations of glutathione S-transferases (GSTs) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent. OBJECTIVE We examined the associations of GSTM1 and GSTT1 null genotypes and GSTP1 313 A/G polymorphisms with endometriosis in an Iranian pop...

Background and aims. The aim of the present study is to determine the incidence of MTHFR C677 T and A1298C muta-tions in Iranian patients with cleft lip and/or cleft palate. Materials and methods. We screened 61 Iranian patients with cleft lip and/or cleft palate for mutations in the two alleles of MTHFR gene associated with cleft lip and/or palate: A1298C and C677T, using Polymerase Chain Reac...