the results obtained in the present investigations point to a definite correlation between the onset of myocardial injury, electrocardiographic changes and biochemical changes. changes in the electrocardiogram and elevated serum levels were paralleled by an increased excretion of magnesium in urine as early as one hour. serum calcium and serum potassium levels did not show any significant resul...

BACKGROUND Alanine transaminase (ALT) and aspartate aminotransferase (AST) are referred to as liver transaminases. Although used routinely in clinical practice for decades, their role as predictors of mortality has not been examined until recently. We studied the predictive value of these serum transaminases in patients with ST-segment elevation myocardial infarction (STEMI) treated with primar...

The alterations in serum pseudo-cholinesterase, transaminases, and aldolase observed in 12 agricultural workers exposed to the organo-phosphorus insecticide, malathion, over a period of six months are recorded. A comparison with a series of unselected controls and a series of manual workers is made. Evidence is produced that the majority of the agricultural workers have been suffering from mino...

Intestinal ischaemia typically presents with signs suggestive of an acute surgical abdomen. A raised serum lactate may substantiate the diagnosis. The first case of ischaemic hepatitis mimicking intestinal ischaemia is reported. The recognition of markedly deranged transaminases allows the clinician to differentiate the two diagnoses and potentially avoid the risks incurred with laparotomy.

A forty-five-day-old female infant presented with prolonged jaundice with clinical features suggestive of congenital hypothyroidism (CHT). On investigations, the infant was noted to have indirect hyperbilirubinemia (13.8 mg/dl) with increased levels of AST (298 IU/dl) and ALT (174 IU/dl) in the serum. The child had low levels of free T3 (<1 pg/ml) and free T4 (0.4 ng/dl) secondary to thyroid ag...

INTRODUCTION This study was designed to scientifically evaluate the effects of an aqueous extract of Muntingia calabura L. (M. calabura), a medicinal herb, on isoproterenol-induced myocardial infarction (MI) in rat models. METHODS Six groups of Wistar albino rats, each comprising six animals, were selected for this study. Group I served as a control, Group II rats were given isoproterenol (20...

BACKGROUND Exposure to chemotherapeutic agents such as acetaminophen may lead to serious liver injury. Calcium deregulation, angiotensin II production and xanthine oxidase activity are suggested to play mechanistic roles in such injury. OBJECTIVE This study evaluates the possible protective effects of the calcium channel blocker amlodipine, the angiotensin converting enzyme inhibitor lisinopr...

Background: Paracetamol (APAP) is the most famous drug used in the world to relieve of pain and used as an antipyretic. Paracetamol overdose induces liver damage and is a well known hepatotoxic drug. This study was aimed to determine the incidence of acidosis in acetaminophen overdose with the time of NAcetyl Cystiene (NAC) administration and correlation of late acidosis and death in acetaminop...

Serum alanine aminotransferase (ALT) and y-glutamyltransferase (y-GT) activities were measured in over 2000 north London blood donors. The results were compared with those from the United States. The percentage of the total donor population with ALT activities above 40 IU/1 in 1986 was greater than that found in our earlier studies in 1973 and 1982 (4*6% compared with 2-8% and 3 1 % , respectiv...