The within-subject and between-subject biological variation of the serum concentrations of follitropin, lutropin, sex-hormone-binding globulin, and testosterone; the ratio between the serum concentrations of testosterone and sex-hormone-binding globulin; and the concentration of testosterone in saliva have been studied in a group of 20 men during 12 months. The between-subject coefficients of v...

BACKGROUND The aim of this study was to assess whether low serum testosterone levels in men with newly diagnosed prostate cancer have an association to the endocrine status, prostate-specific antigen (PSA) levels, Gleason score, and androgen receptor expression. METHODS Besides a full clinical work-up, the following hormones were quantified in men with newly diagnosed prostate cancer by serum...

We investigated the relationships among serum testosterone levels, body fat and muscle mass distribution in women with polycystic ovary syndrome (PCOS). Subjects were 67 women with PCOS (mean age +/- standard deviation, 28.8 +/- 6.6 years). Baseline characteristics included age and height. Trunk-leg fat ratio and trunk-leg muscle ratio were assessed with dual-energy x-ray absorptiometry. Serum ...

Polydimethylsiloxane (Silastic) capsules containing crystalline testosterone were implanted subcutaneously in castrate lambs and evaluated for their ability to (1) provide stable, physiological concentrations of serum testosterone and (2) regulate secretion of LH and FSH. Testosterone was nondectable (< .2 ng/ml) between 12 and 24 weeks of age in the serum of castrate lambs implanted with empty...

OBJECTIVES Testosterone deficiency syndrome (TDS) is common among male patients with chronic kidney disease (CKD). We compared the characteristics of TDS in men with CKD versus renal transplantation (RT) with those of age-matched normal controls. MATERIALS AND METHODS The 129 patients were: RT recipients (n = 25) group I, CKD patients (n = 37) group II, and controls (n = 67). We performed est...

OBJECTIVES The Endocrine Society recommends testosterone therapy only in men with low serum testosterone levels, consistent symptoms of hypogonadism, and no signs of prostate cancer. We assessed screening and monitoring patterns in men receiving testosterone therapy in the U.S. METHODS We conducted a retrospective cohort study of 61,474 men aged ≥40 years, and with data available in one of th...

CONTEXT Hypogonadism is a common clinical situation in male patients with liver cirrhosis. OBJECTIVES The aim of the present study was to evaluate the effects of orthotopic liver transplantation on testosterone, free testosterone and sex hormone-binding globulin in male with advanced liver disease and also to determine the relationship of these changes with Model for End-stage Liver Disease (...