Background: Use of hormone replacement therapy (HRT) may increase the risk of adult-onset asthma in women. Various in vitro studies have reported that estradiol stimulates human mast cell lines causing release of allergic mediators which was not observed in estrogen receptor-alpha (ER-alpha) knockout mice. Thus, estrogen might be a key element in occurrence of asthma. In the present study, we p...

Cell proliferation kinetics during growth of an estrogen receptor-positive human breast carcinoma cell line, T-47D, was defined, and some factors which modify its response to tamoxifen were investigated in vitro. T-47D cells were estrogen responsive when grown in charcoal-stripped fetal calf serum, but the addition of 17 beta-estradiol did not fully restore the growth rate to that observed in t...

clomiphene citrate (cc) has an adverse effect on the quality and quantity of cervical mucus (cm). poor cervical mucus has been reported in 15% of cc-treated women. cc exhibits estrogen agonist and antagonist activities. antiestrogenic activity affecting the endocervical glands is theorized to cause a decrease in cervical mucus quality and quantity. an experimental study was performed to assess ...

Background: Deltamethrin (DTM) is a pyrethroid derivative, which is the most potent products of Type 2 insecticides and acts by delaying the closure of sodium channels. Estrogen as a vascular growth factor on ovarian tissue plays an essential impact further to its involvement in follicular growth. On the other hand, the role of angiogenesis on ovarian tissue in inhibiting the apoptotic provoker...

OBJECTIVES To investigate the role of sex-hormonal changes in idiopathic carpal tunnel syndrome (CTS) among post-menopausal women through measuring estrogen receptor (ER) expression in their transverse carpal ligament (TCL) and serum estrogen level, as well as determine the correlation between these factors and electrodiagnostic parameters and Boston score. METHODS Biopsy samples of TCL were ...

background: use of hormone replacement therapy (hrt) may increase the risk of adult-onset asthma in women. various in vitro studies have reported that estradiol stimulates human mast cell lines causing release of allergic mediators which was not observed in estrogen receptor-alpha (er-alpha) knockout mice. thus, estrogen might be a key element in occurrence of asthma. in the present study, we p...

Clomiphene citrate (CC) has an adverse effect on the quality and quantity of cervical mucus (CM). Poor cervical mucus has been reported in 15% of CC-treated women. CC exhibits estrogen agonist and antagonist activities. Antiestrogenic activity affecting the endocervical glands is theorized to cause a decrease in cervical mucus quality and quantity. An experimental study was performed to as...

OBJECTIVE To determine the effect of estrogen replacement therapy (ERT) on the vaginal flora of postmenopausal women. METHODS Vaginal cultures were obtained from 15 postmenopausal women whose hormonal statuses were documented by serum follicle-stimulating hormone (FSH) and serum estrogen levels. After 8 weeks of ERT, consisting of 0.1 mg of estradiol delivered daily by dermal patch, the vagin...

OBJECTIVE To correlate serum estrogen levels with cognitive functions calculated objectively as per Mini Mental State Examination (MMSE) in the females in reproductive age group and those attaining menopause. MATERIALS AND METHODS This study was conducted in Christian Medical College and Hospital, Ludhiana, Punjab, India. 150 subjects (100 postmenopausal females and 50 regularly menstruating ...