We recently discovered that the antidepressant sertraline is an effective inhibitor of hippocampus presynaptic Na+ channel permeability in vitro and of tonic-clonic seizures in animals in vivo. Several studies indicate that the pro-inflammatory cytokines in the central nervous system are increased in epilepsy and depression. On the other hand inhibition of Na+ channels has been shown to decreas...

BACKGROUND Serotonin reuptake inhibitors (SRIs) have demonstrated consistent efficacy in the treatment of obsessive-compulsive disorder (OCD), while agents that are primarily norepinephrine reuptake inhibitors have not. Comparable efficacy has been demonstrated for SRI and non-SRI antidepressants in uncomplicated major depressive disorder (MDD). This multicenter trial is the first comparison of...

Main results People receiving sertraline maintenance had better psychosocial outcomes compared to placebo (table). Depression recurrence was 6% with sertraline and 23% with placebo maintenance (NNT 6, 95% CI 4 to 15; relative risk reduction 74%, 95% CI 49% to 99%). Symptom re-emergence was 26% with sertraline versus 50% with placebo (NNT 4, 95% CI 3 to 11, relative risk reduction 48%, 95% CI 25...

I read with interest the recent article by Wilson et al (2003). On the basis of a randomised, double-blind placebo-controlled trial, they conclude that sertraline is not effective in preventing recurrent episodes of depression. However, I would like to make certain observations. First, looking at Table 2 (p. 494), we find that the number of patients remaining in the study at 100-week follow-up ...

I read with interest the recent article by Wilson et al (2003). On the basis of a randomised, double-blind placebo-controlled trial, they conclude that sertraline is not effective in preventing recurrent episodes of depression. However, I would like to make certain observations. First, looking at Table 2 (p. 494), we find that the number of patients remaining in the study at 100-week follow-up ...

CONTEXT The efficacy, safety, and tolerability of selective serotonin reuptake inhibitors (SSRIs) in the treatment of adults with major depressive disorder (MDD) are well established. Comparatively few data are available on the effects of SSRIs in depressed children and adolescents. OBJECTIVE To evaluate the efficacy and safety of sertraline compared with placebo in treatment of pediatric pat...

PURPOSE Social anxiety disorder (SAD) is a disabling condition that affects almost 5% of the general population. Many types of drugs have shown their efficacy in the treatment of SAD. There are also some data regarding psychotherapies, but no data are available today about the efficacy of brain stimulation techniques. The aim of the study is to compare the efficacy of noninvasive brain stimulat...

this study was designed to examine the antidepressant effect of celecoxib (200 mg/day) augmentation of sertraline in the treatment of female patients with first episode of major depression over 8 weeks of therapy.thirty female outpatients diagnosed with first episode of major depression, were recruited for this study. participants were randomly assigned into two equal groups receiving either se...

I read with interest the recent article by Wilson et al (2003). On the basis of a randomised, double-blind placebo-controlled trial, they conclude that sertraline is not effective in preventing recurrent episodes of depression. However, I would like to make certain observations. First, looking at Table 2 (p. 494), we find that the number of patients remaining in the study at 100-week follow-up ...

I read with interest the recent article by Wilson et al (2003). On the basis of a randomised, double-blind placebo-controlled trial, they conclude that sertraline is not effective in preventing recurrent episodes of depression. However, I would like to make certain observations. First, looking at Table 2 (p. 494), we find that the number of patients remaining in the study at 100-week follow-up ...