Leptospirosis is a zoonosis caused by pathogenic bacteria of the genus Leptospira. This disease affects several animals and humans. Symptoms leptospirosis can range from mild to severe, may in some cases lead death. For diagnosis leptospirosis, microscopic agglutination test considered “gold standard”; however, it has limitations studies are being conducted develop alternative methods screening...

visceral leishmaniasis (vl) is a zoonotic disease caused by leishmania species. dogs are considered to be the main reservoir of vl. a number of methods and antigen-based assays are used for the diagnosis of leishmaniasis. however, currently available methods are mainly based on direct examination of tissues for the presence of parasites, which is highly invasive. a variety of serological tests ...

background: brucellosis is one of the endemic and a zoonotic disease of the iran. science the rapid diagnosis and quick treatment are very important, selection of a sensitive and specific test solving this problem is of a great importance. the main aim of this study is comparison of routine serologic test with standard elisa test. materials and methods: in this survey, 176 suspected patients wi...

One of the most important QC tests of whole-cell pertussis vaccine (WCPV) is potency test. In this regard, mouse protection test (MPT) is the current potency method, which is associated with severe animal distress and large variability in results. The purpose of this study was to assess Pertussis Serological Potency Test (PSPT) as a serological alternative method to intracerebral challenge in M...

Neonatal diagnosis of congenital toxoplasmosis is based on a combination serological and molecular tests. Maternal screening treatment differ according to national policies may impact the sensitivity diagnostic methods in infants at birth.

OBJECTIVE The aims of this study were to describe the clinical presentation of primary SS (pSS) in a large cohort of patients by assessing the prevalence of the patient subgroups at high risk for severe extraglandular manifestations and to explore the influence of the patients' serological profile on disease severity and on immunosuppressive drug utilization. METHODS Cumulative demographic, c...

Background: Presence of malaria immune factors induced by erythrocytic stages is widely used as an epidemiological approach to diagnose the infection mainly to distinguish the current, recent and past infections. This study was performed to find out the status of malaria, using microscopical and serological (IFA) methods in Bandar-Abbas and Minab, two malarious districts in Hormozgan Province o...

serology and dna techniques are employed for human leukocyte antigen (hla) typing in different transplant centers. results may not always correlate well and may need retyping with different technique. all the patients (with aplastic anemia, thalassemia, and immunodeficiency) and their donors, requiring hla typing for bone marrow transplant were enrolled in the study. serological hla typing was ...

In this paper, we review serological and molecular based methods to identify HIV infection recency. The accurate identification of recent HIV infection continues to be an important research area and has implications for HIV prevention and treatment interventions. Longitudinal cohorts that follow HIV negative individuals over time are the current gold standard approach, but they are logistically...

BACKGROUND Some syphilis patients remain in a serologically active state after the recommended therapy. We currently know too little about the characteristics of this serological response. METHODS We conducted a cohort study using the clinical database from Zhongshan Hospital, Medical College of Xiamen. In total, 1,327 HIV-negative patients with primary, secondary, latent, and tertiary syphil...