Intensive care unit mortality is strongly associated with organ failure rate and severity. The sequential organ failure assessment (SOFA) score is assessed to evaluate its efficacy as a diagnostic indicator. Statistical analyses investigate the SOFA score distributions in the days leading up to patient mortality and patient discharge. It is found that the SOFA score is not an effective predicto...

OBJECTIVE Endotoxins and cytokines play an important role in the pathogenesis of multi-organ failure and mortality in patients suffering from severe Gram-negative bacterial infection. The aim of this study was to determine whether in patients with such infections, use of a haemofilter with enhanced endotoxin haemoadsorption and cytokine removal properties helps to overcome organ dysfunction. ...

INTRODUCTION Recognition of patterns of organ failure may be useful in characterizing the clinical course of critically ill patients. We investigated the patterns of early changes in organ dysfunction/failure in intensive care unit (ICU) patients and their relation to outcome. METHODS Using the database from a large prospective European study, we studied 2,933 patients who had stayed more tha...

Methods We reviewed the data of liver transplant recipients who underwent percutaneous dilational tracheotomy in Baskent University Hospital between January 2010 and March 2015. Collected data included demographics (age, sex, body weight, length); etiology of chronic liver failure; comorbidities; Child, Model for End Stage Liver Disease (MELD), acute physiology and chronic health evaluation II ...

Background. Acute kidney injury (AKI) treated with continuous renal replacement therapy (CRRT) is a severe complication in trauma patients. The aim of the study was to assess primary traumatic injuries and secondary organ failures in severe posttraumatic AKI. Methods. Retrospective review of adult trauma patients admitted to the trauma centre at Oslo University Hospital Ullevål. Injury severity...

CytoSorb(®) (CytoSorbents Corporation, USA) is a novel sorbent hemoadsorption device for cytokine removal. The aim of this study was to examine the clinical use of CytoSorb(®) in the management of patient with septic shock. We used this device as an adjuvant to stabilize a young patient with multi-organ failure and severe sepsis with septic shock. A 36-year-old female patient was hospitalized w...

background: renal complication of leptospirosis is common and its clinical manifestations vary from urinary sediment changes to acute renal failure. the aim of this study was to determine the final outcome of renal involvement in leptospirosis. methods: this longitudinal prospective study included all serologically confirmed cases of leptospirosis with evidence of renal failure. all patients we...