The effects of increasing oxygen delivery (DO2) on oxygen consumption (VO2) in eight patients with septic shock and five patients with hypovolemic shock were studied during fluid resuscitation. In the septic shock group, DO2 increased from 315 +/- 29 to 424 +/- 25 ml/min/m2 (p less than 0.01) and VO2 increased from 134 +/- 8 to 151 +/- 7 ml/min/m2 (p less than 0.01). In the hypovolemic shock gr...

RATIONALE Changes in plasma cytokine levels may predict mortality, and therapies (vasopressin versus norepinephrine) could change plasma cytokine levels in early septic shock. OBJECTIVES Our hypotheses were that changes in plasma cytokine levels over 24 hours differ between survivors and nonsurvivors, and that there are different effects of vasopressin and norepinephrine on plasma cytokine le...

Sepsis, along with the multiorgan failure that often accompanies the systemic inflammatory response syndrome (SIRS), is a leading cause of mortality in the intensive care unit. As many as 700,000 patients develop sepsis annually in the United States. Nearly half of these patients manifest severe sepsis and septic shock. The mortality for septic shock remains approximately 35% to 45%, despite a ...

BACKGROUND The current consensus definition of septic shock requires hypotension after adequate fluid challenge or vasopressor requirement. Some patients with septic shock present with hypotension and hyperlactatemia greater than 2 mmol/L (tissue dysoxic shock), whereas others have hypotension alone with normal lactate (vasoplegic shock). OBJECTIVE The objective of this study was to determine...

STUDY OBJECTIVES To determine possible differences in morbidity and mortality between early and late onset of septic shock in ICU patients. DESIGN Systematic data collection. SETTING Thirty-one-bed, mixed, medicosurgical ICU in a university hospital. PATIENTS All 65 patients who acquired septic shock after admission to the ICU between February 1999 and April 2000. INTERVENTIONS None. ...

During the last years we collected data of abdominal septic shock patients from clinics all over Germany. The mortality of septic shock is about 50%. Septic shock is related to immune system reactions and unusual measurements. Septic shock patients are intensely medicated during their stay at the intensive care unit. To help physicians recognizing the critical states of their patients as early ...

According to the new sepsis definitions, septic shock is defined as a subset of sepsis in which the underlying circulatory and cellular/metabolic abnormalities are profound enough to substantially increase mortality. We evaluated the predictive efficacy of the Sequential Organ Failure Assessment (SOFA) score in critically ill patients with septic shock undergoing pulse indicator contour continu...

CONTEXT The mechanisms of septic shock-associated adrenal insufficiency remain unclear. This study aimed at investigating the synthesis of corticotropin-releasing hormone (CRH) and vasopressin (AVP) by parvocellular neurons and the antehypophyseal expression of ACTH in human septic shock and in an experimental model of sepsis. OBJECTIVE To test the hypothesis that ACTH secretion is decreased ...