Severe sepsis and septic shock are major problems as the result of high rates morbidity andmortality in intensive care units (ICUs). In the presence of septic shock, each hour of delay inthe administration of effective antibiotics is associated with a measurable increase in mortality.Aminoglycosides are effective broad-spectrum antibiotics that are commonly used in ICUs forthe treatment of life...

We present the clinical course of an 11-year-old child with septic pulmonary embolism secondary to community acquired methicillin-resistant Staphylococcus aureus (MRSA) septic deep venous thrombosis. The aim is to emphasize the non-specific symptoms of septic pulmonary embolism in pediatrics, the frequent association with septic deep venous thrombosis and osteomyelitis, and to highlight that MR...

BACKGROUND The lack of a patent source of infection after 24 hours of management of shock considered septic is a common and disturbing scenario. We aimed to determine the prevalence and the causes of shock with no diagnosis 24 hours after its onset, and to compare the outcomes of patients with early-confirmed septic shock to those of others. METHODS We conducted a pragmatic, prospective, mult...

BACKGROUND There are many case reports of septic arthritis complicating invasive pneumococcal disease (IPD); however, no study has compared patients with IPD with septic arthritis to those who didn't develop septic arthritis Thus, we aimed to determine the rates of, and risk factors for, septic arthritis in patients with invasive pneumococcal disease (IPD). METHODS Socio-demographic, clinical...

INTRODUCTION Benzodiazepines and alpha2 adrenoceptor agonists exert opposing effects on innate immunity and mortality in animal models of infection. We hypothesized that sedation with dexmedetomidine (an alpha2 adrenoceptor agonist), as compared with lorazepam (a benzodiazepine), would provide greater improvements in clinical outcomes among septic patients than among non-septic patients. METH...

Severe sepsis and septic shock are major problems as the result of high rates morbidity andmortality in intensive care units (ICUs). In the presence of septic shock, each hour of delay inthe administration of effective antibiotics is associated with a measurable increase in mortality.Aminoglycosides are effective broad-spectrum antibiotics that are commonly used in ICUs forthe treatment of life...

Background: The ultimate goal of the treatment of infectious knee arthritis is to protect the articular cartilage fromadverse effects of infection. Treatment, however, is not always hundred percent successful and has a 12% failurerate. Persistent infection is more likely to happen in elderly patients and those with underlying joint diseases,particularly osteoarthritis. Eradica...

et al in their study in 2001 randomly assigned 263 patients admitted to emergency department with severe sepsis or septic shock to receive either six hours of early goal-directed therapy (egdt) or standard therapy before admission to the intensive care. 130 were randomly assigned to egdt and 133 to standard therapy. demographic characteristic of patients were the same, but in hospital mortality...

Onsite sanitation with septic tanks is popular in most of the Asian countries. The case study conducted in Hanoi and suburban area of Bangkok indicates that the septic tanks employed did not perform as required. The septic tanks just convert the suspended pollutants into dissolved form and release them to the environment due to insufficient maintenance. Thus the effluent from the septic tank is...

BACKGROUND The immature platelet fraction (IPF) reflects the degree of reticulated platelets. We evaluated performances of IPF as a biomarker for the discrimination of septic patients from non-septic patients and sepsis severity. METHODS Total 312 patients admitted between March and July 2013 were enrolled and samples were obtained at admission. Lactate (LA), procalcitonin (PCT), C-reactive p...