Objective: Sepsis animal models commonly fail to predict clinical efficacy of novel therapeutics in humans because most animals are more resistant to pathogens and sepsis is not measured or evaluated in the same manner. We modified the third international consensus clinical criteria for sepsis and septic shock (Sepsis-3) to evaluate and diagnose two swine models of sepsis, as pigs are similar t...

BACKGROUND: Neonatal seizures may be the first and sometimes only clinical symptom of neonatal central nervous system disease. indicate an underlying treatable cause. Therefore, identification is important in management high-risk newborns. OBJECTIVE: To determine frequency sepsis among neonates presenting with seizures. Settings: Department child health, Hayatabad Medical Complex, Peshawar. Dur...

Bacteremia is a bacterial infection that enters the bloodstream. This study was designed to investigate if culture methods could detect of bloodstream and assess certain criteria for sepsis in culturable non-culturable blood samples from hospitalized patients, like C-reactive protein (CRP), lactate dehydrogenase (LDH), complete count (CBC). A total 100 patients with symptoms who resided Hilla C...

Introduction: The elderly represent a significant proportion of the populace and their mortality index is of public health significance. With dearth of vital registration, in-hospital based studies remains a desirable alternative. This study hopes to determine the epidemiologic pattern of elderly mortality with respect to sex, age, date and cause of death.  Methods: This is descriptive retrosp...

After an initial febrile viral syndrome, infection with Ebola virus often induces an explosive late "Ebola sepsis-like syndrome" which appears very similar to some phenotypes of bacterial sepsis and is commonly fatal. It is possible that direct and diffuse viral infection of both the endothelium and epithelium of the colon may cause sufficient disruption of both the endothelial and epithelial b...

Despite a decrease in mortality over the last decade, sepsis remains the tenth leading causes of death in western countries and one of the most common cause of death in intensive care units. The recent discovery of Toll-like receptors and their downstream signalling pathways allowed us to better understand the pathophysiology of sepsis-related disorders. Particular attention has been paid to To...