OBJECTIVE The aim of this study was to evaluate the GoldenGate microarray as a diagnostic tool and to elucidate the contribution of the genes on this array to the development of both nonsyndromic and syndromic sensorineural hearing loss in China. METHODS We developed a microarray to detect 240 mutations underlying syndromic and nonsyndromic sensorineural hearing loss. The microarray was then ...

Dear Editor, Hearing loss is a known outcome following head injury. Ipsilateral transverse type of temporal bone fracture is commonly associated with sensorineural hearing loss. Labyrinthine concussion is believed to be the mechanism of contralateral profound deafness. Our cases illustrate patients who sustained extradural haemorrhage following a motor vehicle accident with profound sensorineur...

Introduction: Pseudoexfoliation syndrome (PXS) occurs due to the deposition of extracellular fibrillar materials on the anterior chamber of the eye. This syndrome has been considered to be part of a systemic disease with the potential involvement of the inner ear called sensoroneural hearing loss (SNHL).  In this study, we aimed on evaluating SNHL within PXS patients in Iran to compare them wi...

Mumps is the most common cause of unilateral acquired sensorineural hearing loss in children. Although it usually affects the salivary glands. the inner ear may be involved. Deafness is usually unilateral, sudden in onset, profound and permanent. Bilateral total sensorineural hearing loss had been rarely reported in English literature. We present a case of total deafness due to asymptomatic mum...

A 12-year-old female patient presented with unilateral sensorineural hearing loss. Distortion-product otoacoustic emission testing failed to reveal any measurable emissions in the affected side. MR imaging did not reveal labyrinthine malformation. Three-dimensional Fourier transformation-constructive interference in steady-state MR images showed a thin cochlear branch. We speculated that mumps ...

The etiology of sensorineural hearing loss is multifactorial which makes the diagnosis a challenging exercise and often an unsolved mystery. Whilst pure tone audiometry is a mandatory investigation, others such as laboratory and radiology are based on clinical evaluation. This paper puts forward a protocol for the investigation for sensorineural hearing loss.

BACKGROUND Congenital rubella syndrome (CRS) can be prevented with appropriate vaccination programs. The prevalence rates of rubella and CRS in Iran are unknown; therefore, the risk of exposure in pregnant women is not clear. The prevalence of CRS in the pre-vaccine period can be estimated by evaluating the proportion of children in the population with sensorineural hearing loss attributable to...

The majority of patients with acute sensorineural hearing loss have peripheral vestibulocochlear disorders such as sudden deafness or Meniere’s disease. However, ischemia of the vertebrobasilar artery can also cause vestibulocochlear symptoms such as sensorineural hearing loss and vertigo [1]. The vertebrobasilar artery supplies the inner ear, brainstem, and cerebellum. Ischemia of the vertebro...