BACKGROUND Modulating early immune response by application of bacteria and their by-products has been suggested as a preventive strategy against the development of allergic diseases. In light of this, the aim of the study was to test the effects of oral administration of bacterial lysates (BL) in a rat model of food allergy. METHODS BL or PBS were administered orally to neonatal Brown Norway ...

While studyihg the localization of Streptococcus viridans at sites of local antigen-antibody reactions in rabbits sensitized to horse serum, Weisberger (Proc. Soc. Exper. Biol. & Med., 1932, 29, 445) observed that there was a difference in the rate of disappearance of these organisms from the blood stream of normal and of sensitive animals. In the case of the sensitive animals, the bacteremia w...

Trimellitic anhydride (TMA) is one of many low molecular weight compounds known to cause occupational asthma. In our previous studies the TMA-induced allergic response in guinea pigs was attenuated by depletion of complement. Specifically, the leakage of red blood cells and infiltration of inflammatory cells into the lung after TMA challenge was significantly reduced. Thus, we hypothesize that ...

OBJECTIVE(S) Different pharmacological effects of carvacrol including relaxant effect, its inhibitory effect on muscarinic and histamine (H1) and stimulatory effect on β-adrenoceptors have been demonstrated on guinea pig tracheal chains in previous studies. In the present study, the effect of carvacrol on blood IL-4, IFN- γ and endothelin levels of sensitized guinea pigs is examined. MATERIAL...

1. A significant cytotoxic effect of trypsinized, sensitized cell cultures was observed when re-exposed to Brucella antigens in vitro. 2. The cytometric assay of the toxic effects of Brucella antigens using trypsinized cells from sensitized animals provides an objective measure of induced cellular hypersensitivity.

Ultrasonically nebulized distilled water-induced bronchoconstriction (UNDW-IB) is specific to asthma. The mechanisms underlying UNDW-IB are not fully understood, and no reproducible animal model has been reported. The purpose of this study was to develop a guinea-pig model of UNDW-IB. Ultrasonically nebulized distilled water (UNDW) was inhaled 20 min after an aerosolized antigen challenge in pa...

Xanthine derivatives may inhibit phosphodiesterases without selective action on their single isoforms. In this study, effects of theophylline and theobromine on cough and airway reactivity were evaluated in awake guinea pigs using double-chamber whole body plethysmograph. Pre-treatment with theophylline and theobromine (10 mg/kg, i.p.) decreased the number of cough efforts evoked by inhalation ...

BACKGROUND Anti-inflammatory effect of natural adjuvants has been reported. Lung inflammation is the most characterized pathological feature in asthma. OBJECTIVES The effects of three natural adjuvants (PC, G2, and G2F registered as a patent in the Iranian Patent Office) on sensitized guinea pigs lungs were examined in the present study. MATERIALS AND METHODS LUNG PATHOLOGICAL CHANGES WERE ...

Sensitivity to the fungus Alternaria is associated with asthma persistence and severity. Current therapeutic options for treating Alternaria-induced airway inflammation are limited. In this study, Brown Norway rats are used to study the effectiveness of a DNA-based vaccine delivered to the airway in attenuating the response to a major Alternaria allergen, rAlt a 2. Compared to untreated sensiti...

1. Typical lethal anaphylactic shock has been produced in guinea pigs by means of the specific carbohydrate derived from a human strain of tubercle bacillus. The phenomenon has been observed in animals both actively and passively sensitized. 2. Typical contractions have been evoked in the isolated uterus of guinea pigs upon the addition of the specific carbohydrate to the bath. 3. True anaphyla...