Several synthetic compounds like thiobisformamidine, dithiobiurets and thiobiurets posses a significant analgesic property (1). Some of them (isothiobiurets, thiobiurets) also potentiate the barbiturate hypnosis and this has generally been linked to an enhanced lipophilic property due to the introduction of sulphur. Partition coefficient (a lipophilic parameter for nvalue) is considered to infl...

This study addressed the design and syntheses of diverse ligands, which were then successfully treated with Ni (II) ion to afford a series of nickel complexes. α-Chloroformylarylhydrazine hydrochlorides contain two different functional groups. One is a strong nucleophile, and the other is a good electrophile. Therefore, it can be designed to react with several reagents to obtain diverse derivat...

В настоящей работе был синтезирован ряд семикарбазонов, в структуру которых входят фенольные фрагменты, проведен конформационный анализ полученных соединений и оценка их антиокислительных свойств. Семикарбазоны, содержащие представляют интерес качестве эффективных антиоксидантов, способных нейтрализовывать свободные радикалы предотвращать окислительный стресс, который связан с широким спектром ...

From QSAR studies, a series of salicylaldehyde semicarbazones, HOC6H4CH=N-NHCONR2 (H2R2) and their Cu(II) complexes were synthesized, characterized and investigated for their biological activities previously. Results obtained showed that one of the most active compounds in this series is [Cu(HBnz2)Cl]. Thus, in this study, research was then carried out to investigate the anti-tumour property of...

3-Aryl-amido/imido-methyl-4-hydroxy-phenyl-acetophenones (I) were prepared in excellent yields by condensing equilmolar amounts or p-hydroxy acetophenones and aryl-amido/imido-alcohols in the presence of conc. H2SO4. Reaction of (I) with semicarbazide, hydro-chloride in ethanol afforded 3-Aryl-amido/imido-methyl-4-hydroxyphenyl-acetophenone-semicarbazones (II) in the yields ranging from 60-70%....