نتایج جستجو برای: selective alkylation
تعداد نتایج: 203893 فیلتر نتایج به سال:
Protein alkylation by 4-hydroxy-2-nonenal (HNE), an endogenous lipid derived electrophile, contributes to stress signaling and cellular toxicity. Although previous work has identified protein targets for HNE alkylation, the sequence specificity of alkylation and dynamics in a cellular context remain largely unexplored. We developed a new quantitative chemoproteomic platform, which uses isotopic...
alkylation of biphenyl with 1-octene was investigated using ((al+c3h7cl)+c2h4) catalysts. the catalytic activity of ((al+c3h7cl)+c2h4) for the alkylation was studied at different temperatures, mol ratios of biphenyl to 1-octene, reaction times and catalyst concentrations. it was shown that using this catalyst has more advantagous than another catalysts. experiments show that by increasing tempe...
Treatment of rat brain membranes with the irreversible opioid ligand cis-3-methylfentanylisothiocyanate (Superfit) was used to reduce gradually the number of available binding sites for the delta-selective agonist [3H][D-Ser2,Leu5]enkephalin-Thr6 ([ 3H]DSLET). Subsequently, the correlation between ligand binding and low-Km GTPase was investigated. Alkylation with 10 microM and 25 microM Superfi...
Flavones were directly alkylated at the C-3 position in moderate yields using a xanthate-based oxidative radical addition procedure. This methodology is a suitable synthetic tool for the direct substitution of the vinylic and unactivated C-H bond of the C ring of the flavone by an alkyl functionality under neutral conditions.
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