نتایج جستجو برای: sedative
تعداد نتایج: 4254 فیلتر نتایج به سال:
In search of bioactive molecules in the class of functionally substituted heterocyclic compounds, we synthesized some new N-(1-methyl-1H-pyrazole-4-carbonyl)thiourea derivatives and evaluated their analgesic and sedative effects. The obtained compounds were characterized by elemental analysis, IR and NMR spectroscopic analyses and evaluated for their analgesic and sedative effects.
BACKGROUND Within the GABA(A)-receptor field, two important questions are what molecular mechanisms underlie benzodiazepine tolerance, and whether tolerance can be ascribed to certain GABA(A)-receptor subtypes. METHODS We investigated tolerance to acute anxiolytic, hypothermic and sedative effects of diazepam in mice exposed for 28-days to non-selective/selective GABA(A)-receptor positive all...
Indiplon (NBI 34060; N-methyl-N-[3-[3-(2-thienylcarbonyl)-pyrazolo[1,5-alpha]pyrimidin-7-yl]phenyl]acetamide), a novel pyrazolopyrimidine and high-affinity allosteric potentiator of GABA(A) receptor function, was profiled for its effects in rodents after oral administration. In mice, indiplon inhibited locomotor activity (ED(50) = 2.7 mg/kg p.o.) at doses lower than the nonbenzodiazepine hypnot...
Studies prove that using aromatherapy with lavender oil generates reduction of anxiety, sedative, antidepressant, soothing, antispasmodic, analgesic and healing effects. A fact occurs due to the inhibitory action on hypothalamic-hypophysis-adrenal axis, which results in release cortisol, stress hormone. Promoting, other hand, serotonin, generating a feeling pleasure well-being. Thus, present st...
asperugo procumbents l. has been used in iranian traditional medicine for the refreshing, tranquillizing and mood elevating activities. the present study was undertaken to evaluate the antidepressant and sedative-hypnotic potential of acute administration of the hydroalcoholic extract of this plant in mice.additionally, the effects of flumazenil on the hypnotic activity of the extracts were eva...
The primary use of sedative–hypnotic and anxiolytic drugs is to encourage calmness (anxiolytics or sedatives) or to produce sleep (sedative–hypnotics). All people are subject to states of emotional tension and uneasiness. For otherwise healthy individuals, these occasions are usually sufficiently mild and short that pharmacological intervention is unnecessary. However, at times the symptoms of ...
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