نتایج جستجو برای: secreted expression
تعداد نتایج: 898666 فیلتر نتایج به سال:
Mesenchymal stem cells (MSCs) have been widely used in regenerative medicine and clinical therapy due to their capabilities of proliferation, differentiation, immune regulation. However, during vitro expansion, MSCs are prone aging, which largely limits application. Prostaglandin E-2 (PGE-2) is a key effector secreted by exert immunomodulatory effects. By screening the compound library for PGE-...
Introduction: Adipose tissue affects body hemostasis by secreting a variety of proteins named adipokines. Plasma levels of apelin decreases after exercise; however, the evidence on gene regulation in adipocytes is rare. The aim of this study was to investigate the association of daily physical activity and applein gene expression and its serum levels in visceral and subcutaneous adipose tissues...
Background and purpose: Ghrelin secreted mainly by stomach in food restriction. This neuropeptide is also expressed in ovary. Although effect of weight loss on reproductive system is obvious but the mechanism of this effect is not fully understood. The aim of this study was investigating the effect of minus energy balance on ghrelin, ghrelin receptor, aromatase, and StAR gene expression in diff...
Abstract Background and objective: Hepcidin is a cystein-rich antimicrobial peptide, which is secreted by the liver. It fights against wide spectrum of bacteria, viruses and fungi and it is a major regulator of iron homeostasis. Today, scientists have made many efforts on the production of hepcidin. Baculovirus expression system is one of the best eukaryotic expression systems for production of...
Abstract Peptidoglycan recognition proteins (PGRPs) participate in insect defense against bacterial pathogens by recognizing cell wall peptidoglycans (PGNs). Here, we identified the PGRP-LB gene white-backed planthopper Sogatella furcifera ( SfPGRP-LB ). is a secreted protein with typical PGN-binding domain and five conserved amino acid (aa) residues required for amidase activity. Expression an...
Abstract Fungal unspecific peroxygenases (UPOs) represent an enzyme class catalysing versatile oxyfunctionalisation reactions on a broad substrate scope. They are occurring as secreted, glycosylated proteins bearing haem-thiolate active site and rely hydrogen peroxide the oxygen source. However, their heterologous production in fast-growing organism suitable for high throughput screening has on...
Hepatocellular carcinoma (HCC) is associated with poor prognosis and fluctuations in immune status. Although studies have found that secreted phosphoprotein 1 (SPP1) involved HCC progression, its independent prognostic value immune-mediated role remain unclear. Using The Cancer Genome Atlas Gene Expression Omnibus data, we low expression of SPP1 significantly improved survival patients correlat...
Regular physical activity protects against several types of diseases. This may involve altered secretion of signaling proteins from skeletal muscle. Our aim was to identify the most abundantly secreted proteins in cultures of human skeletal muscle cells and to monitor their expression in muscles of strength-training individuals. A total of 236 proteins were detected by proteome analysis in medi...
Cells communicate with one another not only by cell-cell contact, but also via the elaboration of soluble mediators or cytokines. The functionally distinct repertoire of secreted cytokines of Th1/Th2 cells has been shown to play an important role in the pathogenesis of inflammatory diseases. Effector Th1 cells secretes predominantly IFN- γ and IL-2 and regulates cell-m...
HaCaT as well as human primary keratinocytes constitutively expressed mRNA of the human secreted phospholipase A(2) subtype groups X, V, IIA, and IID. A similar expression pattern was also found in human skin biopsies. Protein analysis showed that under serum-free conditions only group X secreted phospholipase A(2) is secreted into cell culture supernatants of HaCaT as well as human primary ker...
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