Hygroscopicity of the submicrometer aerosol at the high-alpine site Jungfraujoch, 3580 m a.s.l., Switzerland S. Sjogren, M. Gysel, E. Weingartner, M. R. Alfarra, J. Duplissy, J. Cozic, J. Crosier, H. Coe, and U. Baltensperger Laboratory of Atmospheric Chemistry, Paul Scherrer Institut, 5232 Villigen, Switzerland School of Earth, Atmospheric and Environmental Science, University of Manchester, U...

Objectives Membrane bound receptor for advanced glycation end products (RAGE) is over-expressed in response to increasing concentrations of its ligand (eg S100A12) and triggers an inflammatory immune response. Its truncated form sRAGE acts as decoy receptor and competes for ligands thus down-modulating inflammation. Decreased sRAGE levels are associated with rheumatoid arthritis, Sjogren syndro...

The triad of keratoconjunctivitis sicca (KCS), salivary gland involvement (increase in size or xerostomia), and rheumatoid arthritis was described by Sjogren (1933) as a rare syndrome. Any two of the triad were sufficient to make the diagnosis. Subsequently the syndrome has been extended to include disseminated lupus erythematosus (Morgan, 1954; Ramage and Kinnear, 1956; Bain, 1960), systemic s...

primary sjorgen syndrome is one of the commonest autoimmune diseases with characteristic of involvement of lachrymal and salivary glands, but other organ involvements as peripheral and central nervous system are also possible. the reported case is a 23 year old lady presented with progressive sensory ataxia and weakness of four limbs, bilateral sensory hearing loss and cognitive impairment with...

There are as many as one-third of the systemic lupus erythematosus (SLE) patients who suffer from dry eye syndrome. To this date, dry eye syndrome in SLE patients is believed to be caused by secondary Sjogren syndrome (sSS). However, there is increasing evidence for possible independency of dry eye syndrome and sSS in patients suffering from autoimmune diseases. The purpose of this retrospectiv...

Background: Sparse data are available in literature about pattern of nasal affection in Sjogren syndrome (SS). Objective: To study the ultrastructural changes in the nasal mucosa in SS patients with nasal dryness. Methods: Light microscopy and transmission electron microscopy (TEM) of anterior end of inferior turbinate in 14 patients with SS experiencing nasal dryness and five healthy controls ...