Salvia chorassanica Bunge is one of the Iranian endemic species of Salvia. There is not any reported literature on S. chorassanica. This study was designed to examine the in-vitro anti-proliferative and proapoptotic effects of the methanol extract of S. chorassanica and its fractions on HeLa cell line. Cells were cultured in EX-CELL®, an animal free medium specially designed for HeLa cell line ...

colon cancer is cancer of the large intestine (colon), the lower part of digestive system and the third most common cancer in men and the second most common cancer in women worldwide. genetic background is thought to play a role in modulating individual risk to this cancer. many studies support an association for insulin pathway gene polymorphisms and   the regulation of tumor cell biology in c...

Background: Activation of the ubiquitin-proteasome pathway in various malignancies, including colorectal cancer, is established. This pathway mediates the degradation of damaged proteins and regulates growth and stress response. The novel human gene, UBE2Q2, with a putative ubiquitin-conjugating enzyme activity, is reported to be overexpressed in some malignancies. We sought to investigate the ...

Salvia chorassanica Bunge is one of the Iranian endemic species of Salvia. There is not any reported literature on S. chorassanica. This study was designed to examine the in-vitro anti-proliferative and proapoptotic effects of the methanol extract of S. chorassanica and its fractions on HeLa cell line. Cells were cultured in EX-CELL®, an animal free medium specially designed for HeLa cell line ...

Membrane proteins that are tagged with ubiquitin are diverted from the secretory pathway into lysosomes. New work shows that it is the GGA proteins that initiate sorting in the Golgi, and suggests that similar principles apply to multiple sorting steps.

taxol is used to treatment of variety cancers including ovarian, breast, lung, head and neck carcinomas and the aids-related karposi’s carcinoma, and was originally obtained from bark of taxus brevifolia. however the amount of extracted taxol from taxus is extremely low and cannot be considered as a suitable commercial source and it has led to studies for finding new sources of taxol. in 1998, ...

introduction: intranodal pathways of atrioventricular (av) node play a vital role in the delay of conduction time in response to various atrial inputs. the present study was aimed to determine the frequency-dependent electrophysiological properties of concealed slow pathway according to a functional model of isolated rabbit atrioventricular node preparation after fast pathway ablation. methods:...

materials and methods total protein was determined by lowery method. bovine lens alr2 was partially purified by gel filtration chromatography on sephadextm g25. bovine cortex kidney alr1 was partially purified by diethylaminoethyl (deae) precipitation. the hydroalcoholic extract was obtained from frozen propolis. the enzyme activity and sorbitol accumulation in erythrocytes were determined spec...

Neurokinin 1 receptors (NK1R) are overexpressed on several types of important human cancer cells. Substance P (SP) is the most specific endogenous ligand known for NK1Rs. Accordingly, a new SP analogue was synthesized and evaluated for detection of NK1R positive tumors. [6-hydrazinopyridine-3-carboxylic acid (HYNIC)-Tyr8-Met(O)11-SP] was synthesized and radiolabeled with 99mTc using ethylenedia...