RATIONALE Studies of hypoglossal (XII) motoneurons that innervate the genioglossus muscle, an upper airway dilator, suggested that the suppression of upper airway motor tone during REM sleep is caused by withdrawal of excitation mediated by norepinephrine and serotonin. OBJECTIVES Our objectives were to determine whether antagonism of aminergic receptors located in the XII nucleus region can ...

A glycoprotein of mol wt ca. 18,000 daltons isolated from cured tobacco leaves (TGP-L) and from cigarette smoke condensate (TGP-CSC) activated factor XII in normal human plasma in vitro as measured by (a) shortening of the partial thromboplastin time, (b) shortening of the lysis time of euglobulin clots, and (c) generation of kinin activity. These effects were not demonstrable in plasma deficie...

A cDNA for coagulation factor XII has been used to investigate the presence of gene lesions and restriction fragment length polymorphisms in two brothers with Hageman trait and their family. A TaqI polymorphic fragment has been found in the two propositi and in 11 members of the paternal lineage. This polymorphism, absent in the normal population, is correlated with the reduction of factor XII ...

as a result of being hydrogenous moderators, several landmine detection methods based onnuclear techniques have been suggested in recent years. because of elastic scattering and moderating neutrons from hydrogen atoms in landmines, detection of backscattered neutron shows an anomaly in the reflected thermal neutrons count when a detector scans over a mine. on landmine detection using neutron so...

Membrane-bound carbonic anhydrase (CA) facilitates acidification in the kidney. Although most hydratase activity is considered due to CA IV, some in the basolateral membranes could be attributed to CA XII. Indeed, CA IV is glycosylphosphatidylinositol anchored, connoting apical polarization, but CA IV immunoreactivity has been detected on basolateral membranes of proximal tubules. Herein, we de...

The Itai-Itai disease case is one of four major pollution-related lawsuits occurring in Japan after World War H. This paper, which is based on investigations of the pollution source, the Kamioka mine, considers (1) the history of the disturbances to the environment caused by the Kamioka mine; (2) the Itai-Itai disease suit; (3) the pollution nprevention measures and methods of the Kamioka mine ...

water has an important role in creating pollution problems in the mining regimes influencing the surrounding surface environment. the purpose of this study is to make an assessment of groundwater quality in an underground mine site in portugal with a view of determining the pollution potential of groundwater. in the corresponding surface area of this underground mine, intersections of fou...

In this study, an 1888-bp carbonic anhydrase XII (CA XII) sequence was cloned from the brain of the pufferfish, Takifugu rubripes. The cloned sequence contained a coding region of 1470-bp, which was predicted to translate into a protein of 490 amino acid residues. The predicted protein showed between 68-56% identity with the large yellow croaker (Larimichthys crocea), tilapia (Oreochromis nilot...