Telomeres are ribonucleoprotein structures forming a protective buffer at the ends of chromosomes. They preserve integrity genetic material during cell cycle. Replicative telomere erosion can be compensated by telomerase.

NB-003 and NB-003 gel formulations are oil-in-water nanoemulsions designed for use in bacterial infections. In vitro susceptibility of Propionibacterium acnes to NB-003 formulations and comparator drugs was evaluated. Both NB-003 formulations were bactericidal against all P. acnes isolates, including those that were erythromycin, clindamycin, and/or tetracycline resistant. In the absence of seb...

INTRODUCTION Numerous plant products described in the scientific literature show distinct activities on the skin, such as moisturizing, antioxidant, sunscreen, anti-acne and depigmentation. AIM The main objective of this study was to compare the effectiveness of emulsion formulations containing plant extracts (Hippophae rhamnoides and Cassia fistula) and placebo (without plant extracts) on ac...

in this study the influence of azelaic acid (aza) 20% cream on the sebum excretion rate (ser) of 80 volunteers having mild to moderate acne vulgaris was demonstrated. absorbent paper and sebutape were used to collect the sebum and quantification was carried out by direct gravimetric method. it was shown that topical application of aza creams could reduce the ser and number of acneic lesions as ...

This study was performed to analyze the relationship among sebum . hydration content of the skin and nutritional intake, serum antioxidant minerals and antioxidant enzymes, and lipid peroxide concentration in 50 female subjects in their 20s. The skin type was divided into Dry Skin, Mixed Skin, and Oily Skin, and the dry skin group was 14%, the mixed skin group was 56%, and the oily skin group w...

BACKGROUND The effectiveness of ultraviolet (UV) radiation, visible light, or infrared light therapy for the treatment of acne is the subject of ongoing scientific debate. OBJECTIVE This study was conducted to investigate changes in sebum production and the expression of inflammatory cytokines, matrix metalloproteinases (MMPs), and antimicrobial peptides (AMPs), following exposure of cultured...

BACKGROUND Acne vulgaris has been linked to the Western diet. Hyperglycemic diet increases insulin and insulin-like growth factor (IGF)-1. Deeper insights into IGF-1-mediated signal pathway are critical importance to understand the impact of Western diet. OBJECTIVE We investigated the effect of IGF-1 on the expression of inflammatory biomarkers and sebum production in cultured sebocytes. ME...