N, Nbis(2-chloroethyl)aminobenzoyl picolinoyl hydrazide(BABPH), a benzoic acid nitrogen mustard based new compound and its metal complexes(Cu2+ and Zn2+) have been synthesized and characterized by elemental analysis, IR, 1HNMR, EPR, electronic spectrum, and molar conductivity measurements. In the present study, both BABPH and its complexes exhibited in vitro excellent inhibition of L1210, K562 ...

The expression of microRNA 198 which is localized in human chromosome 13q13.3 downregulated many malignant tumors. purpose this study to investigate the regulatory effects on non-small cell lung cancer and associated mechanism. levels lines tumor tissues were determined using reverse transcription polymerase chain reaction method. Overexpression adenocarcinomic alveolar basal epithelial cells, ...

The mechanism of nasopharyngeal carcinoma (NPC) remains unclear. The present study investigated the abnormal expression of long non-coding (lnc)RNAs in NPC tissues and one NPC cell line to identify the involvement of lncRNAs in the tumorigenesis of NPC. Using a quantitative reverse transcription polymerase chain reaction (RT-qPCR), the expression of lncRNA C22orf32-1 in NPC tissues and an NPC c...

BACKGROUND Glioblastoma has highly invasive potential, which might result in poor prognosis and therapeutic failure. Hence, the key we study is to find effective therapies to repress migration and invasion. Sulforaphane (SFN) was demonstrated to inhibit cell growth in a variety of tumors. Here, we will further investigate whether SFN inhibits migration and invasion and find the possible mechani...

Objective(s): This paper aims to investigate synergistic inhibition of polysaccharide from Sepia esculenta ink (SIP), a newly isolated marine polysaccharide in our laboratory, on breast cancer MDA-MB-231 cells exposed to cisplatin. Materials and Methods: Cell viability of MDA-MB-231 cells was determined by CCK 8 assay. Median-effect concentration was analyzed using Chou-Talalay method that was ...