OBJECTIVE Up to now, little was known about the immunological changes of chronic hepatitis C (CHC) patients treated with direct-acting antiviral agents (DAAs); we try to explore the effect of DAAs on the frequency of monocytes, NK cells, and cytokines that promote their activation. METHODS 15 treatment-naive CHC patients and 10 healthy controls were recruited. Patients were examined before DA...

Objective: Observe and analyze the clinical significance of differences in expression levels sCD163, haptoglobin cytokines. Methods: 120 patients with tuberculous pleural effusion diagnosed our hospital from January 2019 to December 2021 were randomly selected as experimental group. On other hand, 40 non-tuberculous admitted same period control The cytokines observed analyzed. Results: sCD163 (...

OBJECTIVE We investigated plasma and flow cytometric biomarkers of monocyte status that have been associated with prognostic utility in HIV infection and other chronic inflammatory diseases, comparing 81 HIV+ individuals with a range of treatment outcomes to a group of 21 healthy control blood donors. Our aim is to develop and optimise monocyte assays that combine biological relevance, clinical...

BACKGROUND Heightened immune activation among human immunodeficiency virus (HIV)-infected persons may contribute to atherosclerosis. We assessed associations of serologic markers of monocyte activation, soluble CD163 (sCD163) and soluble CD14 (sCD14), and monocyte chemoattractant protein 1 (CCL2) with subclinical atherosclerosis among men with and those without HIV infection in the Multicenter ...

Background and aimsThe TNF-superfamily member sTWEAK its scavenger receptor sCD163 are potentially involved in pathophysiological processes of atherosclerosis. In patients with peripheral arterial disease, previous research has shown that the sCD163/sTWEAK ratio were independently associated long term all-cause cardiovascular survival. Since investigations emphasized on symptomatic disease incl...

Introduction: Monocyte counts were found of prognostic significance in DLBCL, implying the possible contribution monocyte-macrophage lineage cells disease pathogenesis. These secrete among others sCD163, role which has not been investigated yet. Aims: To study eventual correlation serum sCD163 levels with prognosis DLBCL. Patients and Methods: Twenty-six DLBCL patients studied a median follow-u...

INTRODUCTION Systemic lupus erythematosus (SLE) is characterized by impaired efferocytosis and aberrant activation of innate immunity. We asked if shedding of MER receptor tyrosine kinase (MerTK) and AXL into soluble (s) ectodomains was related to immunological and clinical aspects of SLE. METHODS Levels of sMER and sAXL in the plasma of 107 SLE patients and 45 matched controls were measured ...

Galectin-1 (Gal-1) is known to regulate cell signaling within the immune system and may be a target for new anticancer immune therapy. In patients with chronic lymphocytic leukemia (CLL) and classical Hodgkin lymphoma (cHL), high levels of Gal-1 within the tumor microenvironment were associated with worse disease state or poor outcome. Gal-1 can be secreted from cells by an unknown mechanism, a...