We study biased control variates (BCVs), whose purpose is to improve the efficiency of stochastic simulation experiments. BCVs replace the control-simulation mean with an approximation; the resulting control-variate estimator is biased. This bias may not be a significant issue for finite sample sizes, however, because our estimator minimizes the more general mean-squared-error (mse), i.e., the ...

Parameters of glucose dynamics recorded by the continuous glucose monitoring system (CGMS) could help in the control of glycemic fluctuations, which is important in diabetes management. Multiscale entropy (MSE) analysis has recently been developed to measure the complexity of physical and physiological time sequences. A reduced MSE complexity index indicates the increased repetition patterns of...

Memory Self-Efficacy (MSE) has been shown to be related to memory performance and social participation in a healthy elderly population. This relation is unclear in stroke. As about 30% of all stroke survivors report memory complaints, there is an urgent need for effective treatment strategies. Before implementing MSE as a potential target in memory training, it should be examined whether the as...

Neural network (NN) based modeling often requires trying multiple networks with different architectures and training parameters in order to achieve an acceptable model accuracy. Typically, only one of the trained networks is selected as "best" and the rest are discarded. The authors propose using optimal linear combinations (OLC's) of the corresponding outputs on a set of NN's as an alternative...

This paper elucidates the conceptual role that independent randomization plays in non-cooperative game theory. In the context of large (atomless) games in normal form, we present precise formalizations of the notions of a mixed strategy equilibrium (MSE) and of a randomized strategy equilibrium in distributional form (RSED). We offer a resolution of two longstanding open problems and show that ...

Stock price forecasting models with lower Mean Squared Error (MSE) are more “welcome" than those who have higher MSE. However, this “welcome" may disappear when lower MSE leads to an unexpected loss whereas higher MSE leads to a positive profit in a practical investment. The reason is that MSE aims to evaluate models in the view of “accuracy", which has nothing to do with profit. We therefore p...

The use of selenomethionine (MSe)-p-cyanophenylalanine (FCN) pairs to probe protein structure is demonstrated. MSe quenches FCN fluorescence via electron transfer. Both residues can be incorporated recombinantly or by peptide synthesis. Time-resolved and steady-state fluorescence measurements demonstrate that MSe-FCN pairs provide specific local probes of helical structure.

Daily averaged TOGA COARE data are analyzed to test our hypothesis that convection is amplified (attenuated) via sub-critical (super-critical) gross moist stability which corresponds to a bottom-heavy (top-heavy) vertical velocity profile. Gross moist stability (GMS) is a quantity which represents efficiency of moist static energy (MSE) export by convection and associated large-scale circulatio...