We performed experiments to determine whether or not acetylcholine exerts a prejunctional inhibitory effect on adrenergic neurotransmission in the human blood vessel wall. Rings of human greater saphenous veins were prepared 2 to 15 hours after death and mounted for isometric tension recording in organ chambers filled with Krebs-Ringer solution. Acetylcholine depressed contractile responses to ...

Introduction: The trend of varicose vein disease seems to be rising globally and its treatment options outcome vary from the institution by institution. Management has also changed high ligation, stripping, avulsion, sclerotherapy minimally invasive endovenous thermal ablation. Methods: A retrospective observational study was carried out find methods lower limb at cardiothoracic vascular surger...

Abstract Background Due to its partially superficial course, the saphenous nerve is vulnerable injury by trauma or surgery potentially leading painful neuroma formation. Different surgical techniques treat have been described, but so far, no one has proven be superior others. The aim of this study was therefore identify factors influencing outcome revision in neuropathic pain our department. Me...

Neuropathic pain is often "spontaneous" or "stimulus-independent." Such pain may result from spontaneous discharge in primary afferent nociceptors in injured peripheral nerves. However, whether axotomized primary afferent nociceptors give rise to pain is unclear. The rostral anterior cingulate cortex (rACC) mediates the negative affective component of inflammatory pain. Whether the rACC integra...