A concise and efficient synthesis of benzo[c]phenanthridines was accomplished by the palladium-catalyzed ring-opening coupling of azabicyclic alkene with o-iodobenzoates, followed by tandem cyclization. The strategy was successfully applied in the total synthesis of benzo[c]phenanthridine alkaloids such as sanguinarine, chelerythrine, nitidine and avicine.

In order to understand the antifungal activity of some derivatives of sanguinarine (S) and chelerythrine (C) and their structure-activity relationships, sixteen derivatives of S and C were prepared and evaluated for in vitro antifungal activity against seven phytopathogenic fungi by the mycelial growth rate method. The results showed that S, C and their 6-alkoxy dihydro derivatives S₁-S₄, C₁-C₄...

Candida species have emerged as important and common opportunistic human pathogens, particularly in immunocompromised individuals. The current antifungal therapies either have toxic side effects or are insufficiently effect. The aim of this study is develop new small-molecule antifungal compounds by library screening methods using Candida albicans, and to evaluate their antifungal effects on Ca...

A study of a simple and sensitive method for the determination of berberine, luguine and sanguinarine in mixtures by normal and synchronous derivative spectrofluorimetry is described. The influence of solvents and other experimental variables is discussed. A three-dimensional plot of both emission-excitation and synchronous spectra obtained by a new software program provides additional informat...

In vivo and in vitro sublethal exposure of abrin, glycyrrhizin (active component of Abrus precatorius seed and root), sanguinarine, protopine (Argemone mexicana seed) and oleandrin (Nerium indicum leaf) inhibited the acetylcholinesterase, lactic dehydrogenase, acid and alkaline phosphatase activity in the nervous tissue of Lymnaea acuminata. The succinic dehydrogenase activity in the nervous ti...