A role for reduced renal nitric oxide production has been proposed as a mechanism responsible for hypertension in Dahl "salt-sensitive" rats. The present study had 2 goals: first, to determine the relationship between changes in mean arterial pressure and renal cortical and medullary blood flows in unanesthetized Dahl/Rapp salt-sensitive (S) and Dahl/Rapp salt-resistant (R) rats as daily salt i...

bstract—A single session of uncontrollable (inescapable ailshock, IS), but not controllable (escapable tailshock, ES), tress is known to selectively potentiate subsequent orphine-conditioned place preference in a dorsal raphe nuleus (DRN) serotonin (5-HT) dependent manner. Here, in ivo microdialysis is used to test the hypothesis that prior IS, ut not ES, will potentiate morphine-induced dopami...

Strehlow, Kerstin, Georg Nickenig, Jörg Roeling, Sven Wassmann, Oliver Zolk, Andreas Knorr, and Michael Böhm. AT1 receptor regulation in salt-sensitive hypertension. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H1701– H1707, 1999.—The molecular events governing salt-sensitive hypertension are currently unknown. Because the reninANG system plays a central role in blood pressure regulation and ...

Salinity is one of the major environmental stresses that limit plant growth and productivity. Glasswort (Salicornia herbacea L.) is one of the native halophytic plants of Iran that widely spread in salt areas. The purpose of this study was to determine the physiological and growth responses of S. herbacea to salinity stress. Plastic pods (15 cm diameter, 20 cm height) with the Silica sand bed w...

This study was undertaken to explore the effects of chronic low-level cadmium ingestion in Dahl hypertension-resistant (R) and hypertension-sensitive (S) lines of rats. Groups of weanling female R and S rats were given 0 or 1 mg cadmium/1. in drinking water and fed either a low salt (0.4% NaCl) or a high salt (4% NaCl) diet for 28 weeks. Cadmium produced hypertension associated with gross cardi...

AIMS Chronic excess salt intake may have blood pressure-independent adverse effects on the heart such as myocardial hypertrophy and fibrosis. Effects of subacute sodium loading with excess dietary salt on diastolic function in normotensive individuals have been conflicting and the mechanisms are poorly understood. METHODS AND RESULTS Thirteen healthy normotensive subjects (age 24 ± 4 years) e...

The in vivo role of mitogen-activated protein kinases (MAPK) in the development of glomerular injury is poorly understood. In the present study, glomerular MAPK activities, including extracellular signal-regulated kinases (ERK), c-Jun NH2-terminal kinases (JNK), and transcriptional factor, activator protein-1 (AP-1) were examined in glomerular injury of salt-induced hypertensive rats. Six-week-...

OBJECTIVE We investigated the mechanism of antihypertensive effects of sodium alginate oligosaccharides, which are enzymatic products of high-molecular-weight natural alginate from seaweeds, in Dahl salt-sensitive (Dahl S) rats. MATERIALS AND METHODS Dahl S rats fed a high-salt (4% NaCl) diet were subcutaneously administered sodium alginate oligosaccharides (60 mg/day using a continuous osmot...

In this study, some physiological and biochemical responses of Synechococcus elongatus to salt stress were investigated. The cyanobactrium was grown in BG-11 medium under different concentrations of NaCl (0, 0.5, 1 M). The results indicated that the growth of S. elongatus was significantly inhibited under salt stress on days 5, 9 and 12. Protein content increased in S. elongatus on day 12 in pr...