INTRODUCTION alpha-Fodrin is an autoantigen in Sjögren's syndrome. We hypothesized that mucosal administration of alpha-fodrin might prevent the disease. METHODS Four-week-old NOD mice were immunized (intranasal) with a 1 microg or 10 microg dose of alpha-fodrin every other day. PBS 10 microl/dose and Glutathione transferase (GST 10 microg/dose (control mice) were intranasally administrated b...

Dental caries is one of the most prevalent chronic diseases. Early detection prominent to avoid tooth weakening or worst loss. UV absorption spectroscopy a non-invasive techniqueused for salivary alpha-amylase which are increasing in presence caries. Spectrum acquired from patient at Faculty dentistry, UKM showed significant peak around 260-300nm correspond amino acid found alpha-amylase.The sp...

The gustatory system plays a critical role in determining food preferences and food intake, in addition to nutritive, energy and electrolyte balance. Fine tuning of the gustatory system is also crucial in this respect. The exact mechanisms that fine tune taste sensitivity are as of yet poorly defined, but it is clear that various effects of saliva on taste recognition are also involved. Specifi...

Abstract Background Oral potentially malignant lesions (OPML) are suspicious that may turn into malignancy according to the degree of dysplasia. Early diagnosis these allows their treatment before transformation. Saliva is a liquid biopsy can be obtained easily from patient and assessed for biomarkers expression. Our study aimed investigate possibility using salivary serum TNF-α Ki-67 in early ...

The value of salivary biomarkers for diagnostic and prognostic assessments has become increasingly well established in medicine, pharmacology, and dentistry. Certain salivary components mirror the neuro-endocrine status of the organism. Other saliva products are protein in nature, and can serve to reflect immune surveillance processes. The autonomic nervous system regulates the process of saliv...