An evaluation and review of a structurally related group of fragrance materials.

In spite of the large use of salicylates, introduced into clinical practice more than 100 years ago, their anti-inflammatory and cancer preventive mechanisms are still under study. Teratogenic effects of salicylates have been reported in experimental animals since 1959 but the pathogenic pathways and the mechanisms of action were never described until now. The aim of this work is to verify if t...

Binding of plasma Factor VII/VIIa to the tissue factor (TF) receptor initiates the coagulation protease cascades. TF expression by circulating monocytes is associated with thrombotic and inflammatory complications in a variety of diseases. Transcriptional activation of the human TF gene in monocytic cells exposed to bacterial lipopolysaccharide (LPS) is mediated by binding of c-Rel/p65 heterodi...

Recent trials show salicylates improve glycemic control in type 2 diabetes, but the mechanism is poorly understood. Expression of the glucocorticoid-generating enzyme 11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1) in adipose tissue is increased in vitro by proinflammatory cytokines and upregulated in obesity. 11b-HSD1 inhibition enhances insulin sensitivity. We hypothesized that salicylates...

Recent trials show salicylates improve glycemic control in type 2 diabetes, but the mechanism is poorly understood. Expression of the glucocorticoid-generating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in adipose tissue is increased in vitro by proinflammatory cytokines and upregulated in obesity. 11β-HSD1 inhibition enhances insulin sensitivity. We hypothesized that salicylates...

The relation of acute thrombocytopenic purpura (TP) to the use of drugs was investigated in a case-control study conducted in eastern Massachusetts, Rhode Island, and the Philadelphia region; 62 cases over the age of 16 years with acute onset and with a rapid recovery were compared with 2,625 hospital controls. After control for confounding by multiple logistic regression, use of the following ...

Children suffering from acute rheumatic fever are usually treated with the hormone preparations, cortisone and A.C.T.H., or with salicylates. Almost always symptoms are rapidly alleviated and clinical signs of activity subside. In a number of cases discontinuance of treatment when the disease process seems to be quiescent is followed by an apparent recrudescence. This feature has become known a...

Children suffering from acute rheumatic fever are usually treated with the hormone preparations, cortisone and A.C.T.H., or with salicylates. Almost always symptoms are rapidly alleviated and clinical signs of activity subside. In a number of cases discontinuance of treatment when the disease process seems to be quiescent is followed by an apparent recrudescence. This feature has become known a...

Long before the time of Hippocrates man began to apply the bark of the willow tree to the successful symptomatic therapy of various disorders that were either painful, inflammatory, or febrile. Subsequently, its active ingredients, salicylates, have been identified, purified, synthesized, and derived upon to yield several useful drugs, most notably, aspirin. Today, salicylates have established ...