(Salen)Mn(III) catalysts show increased turnover numbers in the catalytic asymmetric epoxidation of conjugated olefins upon addition of bulky Lewis acids (LA) such as zinc tetraphenylporphyrin (ZnTPP). Up to 3-fold increase in total catalytic activity and at least a 20-fold increase in catalyst stability was observed with a (salen)Mn catalyst bearing pendant 5,5′-bis-pyridyl groups. This latter...

A new water-soluble, salen [salen = bis(salicylidene) ethylenediamine]-based ligand, 3 was developed. Two of the metal complexes of this ligand, i.e., 3a, [Mn(III)] and 3b, [Ni(II)], in the presence of cooxidant magnesium monoperoxyphthalate (MMPP) cleaved plasmid DNA pTZ19R efficiently and rapidly at a concentration approximately 1 microM. In contrast, under comparable conditions, other metal ...

We report the synthesis of the first 2',3'-diamino substituted uridine derivative with xylo-configuration, its use as starting material for the synthesis of salen-type ligands and the first structurally characterised copper(II) complex thereof.

A chiral Mn(salen) complex exhibiting two lactam binding sites at two rigid 1,5,7-trimethyl-3-azabicyclo[3.3.1]nonan-2-one skeletons is capable of enantioselective sulfoxidation due to spatially remote substrate hydrogen bonding.

A new lipophilic Ru salen complex with cholesterol groups can be efficiently incorporated into liposome bilayers, allowing the photoinduced release of nitric oxide (NO) and the membrane transport of NO to coexisting liposomes.

The solid catalyst with high catalytic activity and enantioselectivity in the hydrolytic kinetic resolution (HKR) of epoxides was prepared by confining Co(Salen) in the nanocage of SBA-16 through reducing the pore entrance size using a silylation method. It was found that the activity of the solid catalysts increased with the number of [Co(Salen)] molecules per nanocage increasing, and the soli...

In the trinuclear title complex, di-μ-acetato-1:2κ(2)O:O';2:3κ(2)O:O'-bis-{μ-6,6'-dimeth-oxy-2,2'-[cyclo-hexane-1,2-diylbis(methanylyl-idene)]diphenolato}-1:2κ(6)O(1),N,N',O(1'):O(6),O(6');2:3κ(6)O(6),O(6'):O(1),N,N',O(1')-2-gadolinium(III)-1,3-dizinc hexa-fluor-idophosphate methanol monosolvate monohydrate, [GdZn2(C22H24N2O4)2(CH3COO)2]PF6·CH3OH·H2O, the two Zn(II) ions are located in the inne...

The formation of a borate-bridged dimeric aluminum Schiff-base compound [salen(Bu)Al]2O2BOMe [salen=N,N’-ethylenebis(salicylidenimine) (1) has been reported. Complex 1 crystallizes in a triclinic P space group with a=14.57, b=15.15, c=15.84 Å and a=96.92, b=90.82, g=105.538. The crystal structure shows the presence of a metaborate (MeOBO2 2– ) bridge between two five-coordinate aluminum atoms w...

Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207, are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative stress. As oxidative stress is implicated in some forms of delayed radiation injury, we are investigating whether these compounds can mitigate injury to normal tissues caused by ionizing radiation. This review describes ...