OBJECTIVE To review the evidence for the use of intravenous salbutamol, its systemic effects and the potential complications that may occur in patients with severe asthma. DATA SOURCES A review of articles reported on intravenous salbutamol in patients with acute asthma. SUMMARY OF REVIEW Intravenous salbutamol is recommended in the treatment of severe asthma when there is failure to respon...

The objective of this study was to determine the particle size and mass output of salbutamol from different nebulizers used under simulated breathing conditions. Seven nebulizer/compressor combinations were assessed. Each nebulizer was charged with 5 mg salbutamol solution and connected to a breathing simulator operating at tidal volumes of 150 mL and 600 mL. Nebulizers were operated for 15 min...

Isoproterenol, a catecholamine acting as a β adrenergic agonist, is commonly used to establish myocardial infarction (MI) in animal models for drug development. Although cheaper than isoproterenol, salbutamol is another type of catecholamine, may be potentially and equally used for the onset of MI in animal model. However the concentrations of salbutamol for inducing MI need to be optimized and...

Background—On the basis of the presence of b2-receptors within the sympathetic nervous system, b2-stimulation may increase cardiac sympathetic outflow. We addressed the hypothesis that sympathoexcitatory b2-receptors are present in the human left ventricle. Methods and Results—The b2-agonist salbutamol was infused into the left coronary artery in 3 groups of patients: group 1 (n59, no b-blocker...

An aerosol formulation containing 7.5 mg of R-salbutamol sulfate was developed. The aerosol was nebulized with an air-jet nebulizer, and further assessed according to the new European Medicines Agency (EMA) guidelines. A breath simulator was used for studies of delivery rate and total amount of the active ingredient at volume of 3 mL. A next generation impactor (NGI) with a cooler was used for ...

Spinal muscular atrophy (SMA) is a common autosomal recessive neuromuscular disorder that is currently incurable. SMA is caused by decreased levels of the survival motor neuron protein (SMN), as a result of loss or mutation of SMN1. Although the SMN1 homolog SMN2 also produces some SMN protein, it does not fully compensate for the loss or dysfunction of SMN1. Salbutamol, a β2-adrenergic recepto...

Many asthma patients remain symptomatic despite maintenance therapy with inhaled corticosteroids (ICS) and salbutamol as rescue medication. In the present study the relative efficacy and preference for as-needed formoterol compared with salbutamol was examined. In total, 211 patients with a mean age of 45 yrs (mean forced expiratory volume in one second (FEV1) 77% predicted normal), using ICS, ...

BACKGROUND The adverse effects of long term treatment of asthma with the short acting beta agonist fenoterol have been established in both epidemiological and clinical studies. A study was undertaken to investigate the efficacy and safety of long term treatment with salbutamol and salmeterol in patients with mild to moderate bronchial asthma. METHODS In a two centre double dummy crossover stu...

Occupational asthma after exposure to salbutamol in the pharmaceutical industry has not been previously reported. The occurrence of occupational asthma is described in two pharmaceutical process workers who were likely to have inhaled doses appreciably in excess of the therapeutic dose range. The findings do not lead to an unequivocal conclusion on the mechanism of the asthma but it was probabl...