An important distinction is frequently made between constitutively expressed housekeeping genes versus regulated genes. Although generally characterized by different DNA elements, chromatin architecture and cofactors, it is not known to what degree promoter classes strictly follow regulatability rules and which molecular mechanisms dictate such differences. We show that SAGA-dominated/TATA-box ...

Zingerone enhances glutamatergic spontaneous excitatory transmission by 1 activating TRPA1 but not TRPV1 channels in the adult rat substantia gelatinosa 2 3 Hai-Yuan Yue, Chung-Yu Jiang, Tsugumi Fujita, and Eiichi Kumamoto 4 5 Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan 6 7 Running head: glutamatergic transmission enhancement by zingerone 8 9 Number of f...

Synaptic modulation and inward current produced by oxytocin in 1 substantia gelatinosa neurons of adult rat spinal cord slices 2 3 Chang-Yu Jiang, Tsugumi Fujita, and Eiichi Kumamoto 4 5 Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, 6 Japan 7 8 Running head: effect of oxytocin on synaptic transmission 9 10 Number of figures: 10; number of pages: 45; number of wo...

The Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex is a transcriptional coactivator with histone acetylase and deubiquitinase activities that plays an important role in visual development and function. In Drosophila melanogaster, four SAGA subunits are required for the deubiquitination of monoubiquitinated histone H2B (ubH2B): Nonstop, Sgf11, E(y)2, and Ataxin 7. Mutations that disrupt SAGA deub...

Acetylcholine and Norepinephrine Mediate GABAergic but not 1 Glycinergic Transmission Enhancement by Melittin in Adult Rat 2 Substantia Gelatinosa Neurons 3 4 Tao Liu, Tsugumi Fujita, and Eiichi Kumamoto 5 6 Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, 7 Japan; Department of Pediatrics, Medical College of Nanchang University, Nanchang 8 330006, China 9 10 Runni...

Acetylation of histone proteins by the yeast Spt-Ada-Gcn5-acetyltansferase (SAGA) complex has served as a paradigm for understanding how posttranslational modifications of chromatin regulate eukaryotic gene expression. Nonetheless, it has been unclear to what extent the structural complexity of the chromatin substrate modulates SAGA activity. By using chromatin model systems, we have found that...

The abundance of middleware to access grids and clouds and their often complex APIs hinders ease of programming and portability. The Open Grid Forum (OGF) has therefore initiated the development and standardization of SAGA: a Simple API for Grid Applications. SAGA provides a simple yet powerful API with high-level constructs that abstract from the details of the underlying infrastructure. In th...

We analyze a fast incremental aggregated gradient method for optimizing nonconvex problems of the form minx ∑ i fi(x). Specifically, we analyze the Saga algorithm within an Incremental First-order Oracle framework, and show that it converges to a stationary point provably faster than both gradient descent and stochastic gradient descent. We also discuss a Polyak’s special class of nonconvex pro...

In this work we introduce a new optimisation method called SAGA in the spirit of SAG, SDCA, MISO and SVRG, a set of recently proposed incremental gradient algorithms with fast linear convergence rates. SAGA improves on the theory behind SAG and SVRG, with better theoretical convergence rates, and has support for composite objectives where a proximal operator is used on the regulariser. Unlike S...

The aims of this study are to develop interpretation structural geology in lithosequent using DEM and finite elemen method based on VES data. This research was conducted June 2021 untill January 2022 at Pasang District, North Toraja. Four main point location were selected recorded google earth. Those points processed software QGIS for developing 3D model, Saga-GIS interpolated generating 1D 2D ...