OBJECTIVES The aim of the present study was to investigate immunotoxic effect of safranal (SAF), a main component of Crocus sativus essential oil, using Balb/c mice. MATERIALS AND METHODS SAF was administered intraperitoneally at doses of 0.1, 0.5 and 1 ml/kg for 3 weeks. Hystopathological examination of spleen and bone marrow, cellularity of spleen, delayed type of hypersensitivity (DTH) res...

Cancer continues to represent the largest cause of mortality in the world and claims over 6 million lives each year (Abdullaev et al., 2000). An extremely promising strategy for cancer prevention today is chemoprevention, which is defined as the use of synthetic or natural agents (alone or in combination) to block the development of cancer in human beings (Abdullaev et al., 2004).It is a hotspo...

in order to investigate the effects of high corm planting density and applying manure on flower and corm yields of saffron (crocus sativus l.), a field experiment was conducted at research station, faculty of agriculture, ferdowsi university of mashhad, iran, during growing season of 2010-2011. a completely randomized block design with three replications and 20 treatments was used. the experime...

Objective: There are different pathophysiological mechanisms for obsessive- compulsive disorder (OCD) as suggested by the serotonergic, dopaminergic, and glutamatergic hypotheses. The present study aimed at comparing the efficacy and safety of saffron (stigma of Crocus sativus) and fluvoxamine in the treatment of mild to moderate obsessive- compulsive disorder. Method: In this study, 50 males a...

Saffron (Crocus sativus) is the most expensive spice in world and a valuable medicinal plant. In this study, flowering, vegetative growth performance, daughter corm formation of potted saffron were investigated six growing media: loamy soil, silty sandy peatmoss, peatmoss + foam. The highest values stigma fresh weight, root number diameter corms observed plants grown soil with light texture, i....

Production of Saffron (Crocus sativus L.) is expanding in both the traditional and non-native areas Jammu Kashmir, India. A study was carried out to develop a cost-effective production system module at ARSSSS, SKUAST-Kashmir, Pampore determine suitable corm weight planting density for saffron. The treatments current includes 3 levels (W1= < 8g, W2= 8-12g W3 = >12g) 5 densities viz., 15 lakh den...

Objective(s):The aim of this study was to investigate the effects of nutritional saffron (Crocus sativus L.) stigma hydroalcoholic extract on blood pressure (BP) and histology of the aorta in normotensive and hypertensive rats. Materials and Methods:   Saffron (200 mg/kg/day) was given orally for 5 weeks to normotensive and hypertensive rats. Hypertension was induced by NG-nitro-L-arginine meth...

Anxiety disorders and schizophrenia are common public health issues. The dried stigma of the plant Crocus sativus L., (C. sativus) commonly known as saffron are used in folk medicine for various purposes. Several lines of evidence suggest that C. sativus, crocins and safranal are implicated in anxiety and schizophrenia. Here, I intend to critically review advances in research of these emerging ...