Targeted therapies and immune checkpoint inhibitors have advanced the treatment landscape of Renal Cell Carcinoma (RCC) over last decade. While demonstrated survival benefit are currently approved in front-line second-line settings, primary secondary resistance is common. A comprehensive understanding mechanisms evasion RCC therefore critical to development effective combination strategies. Thi...

•Electro-oxidative C–H phosphorylation of arenes and alkenes•Chemical oxidants are not required in an undivided cell setup•Sustainable 3d nickela-electrocatalysis with H2 as the only byproduct•Mechanistic insights by NMR spectroscopy, X-ray analysis, mass spectrometry, CV Phosphorus-containing molecules play a pivotal role numerous applied areas have transformative applications molecular synthe...

•Simple urea oligomers organize themselves with a single coherent hydrogen-bond chain•Reversing the polarity of hydrogen bonding sends message through molecule•Conformational messages can be transmitted by changes in pH or anion binding•Receipt conformational is indicated remote fluorescent response Despite progress made synthetic chemistry building molecular structures nature, there are still ...

•Thermal isomerization pathways of donor-acceptor Stenhouse adducts are tuned by polarity•Non-selective stimuli produce selective responses in the DASA mixture Natural systems such as cells or organisms consist thousands stimulus-responsive and adaptive molecules assemblies enzymes proteins. To achieve a multitude selectivity despite limited set available stimuli, nature relies on highly contro...

•Distinguishing gating and pore-opening actions of flexible adsorbents•Tuning energy barrier avoiding pore opening for molecular sieving•Molecular sieving CO2/N2 CO2/CH4•Role host-guest interaction at the moment Molecular sieving, relying on simple size exclusion mechanism, is ideal adsorptive separation. While guest diffusion are generally judged by pore/aperture molecule sizes, precise determ...

The objective was to determine if a relationship exists between participation in a school breakfast program and measures of psychosocial and academic functioning in school aged children. Information on participation in a school breakfast program, school record data, and in depth interviews with parents and children were collected in 1 public school in Philadelphia, PA, and 2 public schools in B...