Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes. Precise clinical evaluation, laboratory testing, pulmonary function testing, radiological imaging including high-resolution computed tomography and often histopathological assessment contribute to make a confident diagnosis of granulomat...

matoid disease on histologic evaluation of the pulmonary and subcutaneous lesions together. The pulmonary lesion had extensive fibrosis, as well as necrosis, and appeared to be a late relatively quiescent lesion. Angiitis was found within but not outside this lesion. Granulomatous infection was unlikely because cultures of the sputum and lung biopsy failed to grow mycobacterial or fungal organi...

Lymphomatoid granulomatosis is an uncommon disorder that can present as multiple pulmonary nodules. Systemic manifestations such as fever, weight loss, skin lesions, and other organ involvement may occur. The clinical presentation of lymphomatoid granulomatosis can mimic infectious diseases (eg, tuberculosis), vasculitis, or metastatic malignancies.1 Lymphomatoid granulomatosis should be consid...

2. Guiñazú Álvarez A, Matteoda M, Tempra A. Granulomatosis linfomatoidea: manifestaciones pulmonares de una entidad infrecuente. RAR. 2006;70:289–92. 3. Frazier AA, Rosado-de-Christenson ML, Galvin JR, Fleming MV. Pulmonary angiitis and granulomatosis: radiologic–pathologic correlation. Radiographics. 1998;18:687–710. 4. Ammannagari N, Gao Z, Deng C, O’Connor O. Lymphomatoid granulomatosis: a d...

Intravenous injection of powdered tablets intended to oral use is a common practice among drug abusers, given the greater effectiveness attributed to accelerate delivery of the drug through this route compared to oral intake. This can result in both acute and chronic changes in the pulmonary vessels and parenchyma. Various terms have been used to describe this entity and include self-induced pu...

Differential diagnosis of infection during active immune disease, such as Wegener's granulomatosis (Wegener's granulomatosis), is a major clinical challenge. Laboratory measures, erythrocyte sedimentation rate or C-reactive protein, can be elevated in infections that supervene, or coinciding with, in active Wegener's granulomatosis, and thus are nonspecific. The aim of the study was to compare ...

Bronchocentric granulomatosis was first described in 19731 and is characterised by a necrotising granulomatous destruction of bronchial walls, bronchioles, and adjacent lung parenchyma. The bronchial lumen is filled by debris and cells, predominantly eosinophils in asthmatic patients and polymorphonuclear leucocytes in non-asthmatic patients.2 Proximal bronchi may show severe chondritis. Any va...

INTRODUCTION Granulomatosis with polyangiitis is characterized by systemic inflammation of medium and small blood vessels. Aortic involvement in granulomatosis with polyangiitis is extremely rare. As far as we know this is the first reported case of successful treatment in a patient with granulomatosis with polyangiitis complicated with aortic aneurysm rupture. CASE PRESENTATION We describe a...

Polyangiitis with granulomatosis, previously known as Wegener's granulomatosis, is a systemic necrotising granulomatous vasculitis. It predominantly affects the upper and lower respiratory tracts and the kidneys, but can potentially affect any organ system. It is diagnosed by clinical features, immunology (anti-neutrophil cytoplasmic antibodies) and histology. Cardiac involvement occurs in 6 to...