-The decrease in hippocampal neurogenesis can lead to development of Alzheimer disease (AD), yet various hypothesis suggest that AD patient have increased neurogenesis in the region 1 of hippocampus proper (CA1 region). Ammon‟s horn (the principle region of Alzheimer‟s pathology) has been found to be involved in neuronal loss however the exact nature of neurogenesis is unknown. Insulin like gro...

UNLABELLED Immunological disturbances have been implicated in the pathogenesis of some neurodegenerative disorders like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Adhesion molecules are markers of activated endothelial cells upregulated by action of cytokines. MATERIALS AND METHODS To investigate the activation or not of the vascular cells in AD and ALS, serum soluble i...

Background: The memory impairment, obtained from intracerebroventricular (i.c.v.) infusion of streptozotocin (STZ) in rats through activation of oxidative stress, is accepted as sporadic Alzheimer’s disease (AD) model in most experimental studies. Dimethyl sulfoxide (DMSO) as a solvent is widely used in animal studies to have antioxidant effects as well. However, no report is available ab...

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by cognitive and other CNS impairments which is increasing worldwide and poses a major public health problem, yet no effective treatments are found and available drugs only alleviate the symptoms temporarily. Postmortem analyses on the brains of AD patients and observed lower risk of AD in NSAIDs users among other studi...

Background: Recent studies have shown that oxidative stress (OS) is the most important indicator in the pathogenesis of Alzheimer's disease (AD), but the results in previous studies are conflicting. This study aimed to assess the plasma levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) as DNA oxidative damage marker and total antioxidant capacity (TAC) in patients with AD versus control group. ...

Alzheimer’s disease (AD) is a progressive neurological disorder characterized by the aggregation of two proteins, amyloid-b and hyper phosphorylated tau, and by neuronal and synaptic loss. The progress of gene-modified cells and stem cells is a particularly promising therapeutic method for AD. Gene-Modified Cell-Based Therapy for AD prior to transplantation can be beneficial for increasin...

alzheimer’s disease (ad), the leading cause of dementia worldwide, is an irreversible progressive neurodegenerative disorder characterized by cognitive impairment and functional disability 1-3. devastating nature of ad leads to serious social and economic impacts on the healthcare systems which implies the necessity of its proper management 1-3. it has been demonstrated that patients’ quality o...

Alzheimer’s disease (AD) is a progressive and irreversible disease which gradually makes patients unable to do their daily routines. Although the present treatments can not cure the disease completely, its early detection can reduce symptoms and enhance the patients’ life quality. In the current literature, using the grey matter (GM) tissue which is known as an appropriate biomarker is highly c...

SUMMARY  Hodgkin's disease has been known to medical practitioners for more than three centuries. The clinical and pathologic description of the disease published by Thomas. Hodgkin first in 183 2 when reported seven cases th-at he considered a new clinical entity.  The incident, clinical feature, histologic, procedure of evaluation and staging of Hodgkin's disease are presented briefly. Part...