Conventional chemotherapy for colorectal cancer (CRC) gives only a small increase in patient survival, since it is often diagnosed at late stages, when the tumor has disseminated to other organs. Moreover, common observe that malignant cells may acquire resistance conventional chemotherapies through different mechanisms, including reducing drug activation or accumulation (by enhancing efflux), ...

Herein is reported the first example of palladium-catalyzed asymmetric allylic alkylation (AAA) reactions involving 2-aza-π-allyl palladium intermediates. The 2-aza-π-allyl complex was generated via a novel mode of activation of N-allyl imines. Pd-catalyzed C(sp3)-H activation of N-allyl imines and subsequent nucleophilic attack by glycinates delivered vicinal diamino derivatives as the sole re...

Thiosulfonates are characterized by a wide spectrum of biological activity and have effective antimicrobial, antithrombotic, antitumor antiparasitic effects. However, the use synthetic sulfur-containing compounds for therapeutic preventive purposes requires study their effect on protective mechanisms maintaining homeostasis, antioxidant status body in particular. The aim was to estimate lipid p...

Purpose Renal failure is an end-stage consequence after persistent hyperglycemia during diabetic nephropathy (DN), and the etiology of DN has been linked to oxidative stress. The purpose this research was determine beneficial synergistic effects S-Allyl Cysteine (SAC) Taurine (TAU) on damage in kidneys type 2 rats induced by hyperglycemia. Design/methodology/approach Experimental diabetes devel...

Objective(s): Allylbenzenes have been recently developed as inhibitors of lipoxygenases. They decrease peroxidation activity via mimicking 1,4-unsaturated bonds of fatty acids by their allyl portion. We designed and synthesized new derivatives of allyl benzenes (6a-f) with isopropoxy and amide substituents at ortho and meta positions towards allyl group, respectively. ...