In this study, a novel mesoporous silica nanoparticles drug carrier contributes to improving the solubility, dissolution, and the oral bioavailability of apigenin (AP). The apigenin of solid dispersion of mesoporous silica nanoparticles (AP-MSN) was prepared by physical absorption method and also, in-vitro drug release and in-vivo bioavailability performance were evaluated. Based on its solubil...

although there is enough knowledge indicating on the influence of frequency content of input motion on the deformation demand of structures, state-of-the-practice seismic studies use the intensity measures such as peak ground acceleration (pga) which are not frequency dependent. the v max/a max ratio of strong ground motions can be used in seismic hazard studies as the representative of frequen...

The aim of the present study was to morphologically and electrically characterize synthetic strands of mouse ventricular myocytes. Linear strands of mouse ventricular myocytes with widths of 34.7+/-4.4 microm (W(1)), 57.9+/-2.5 microm (W(2)), and 86.4+/-3. 6 microm (W(3)) and a length of 10 mm were produced on glass coverslips with a photolithographic technique. Action potentials (APs) were mea...

Introduction: Diagnostic reference level (DRL) is a useful tool for the promotion of optimization. The national DRLs (NDRLs) are useful, brief, and robust guidelines for optimizing radiation protection in a country. The aim of this study was to extract the local DRLs (LDRLs) for some common radiologic examination in Sabzevar county. Materials and Methods: There are eight radiology departments ...

In this study, a novel mesoporous silica nanoparticles drug carrier contributes to improving the solubility, dissolution, and the oral bioavailability of apigenin (AP). The apigenin of solid dispersion of mesoporous silica nanoparticles (AP-MSN) was prepared by physical absorption method and also, in-vitro drug release and in-vivo bioavailability performance were evaluated. Based on its solubil...

INTRODUCTION The cardiac action potential (CAP) of stem cell-derived human cardiomyocytes (SC-hCMs) is potentially the most powerful preclinical biomarker for cardiac safety and efficacy in humans. Our experiments tested this hypothesis by examining the CAP and relevant pharmacology of these cells. METHODS The electrophysiological and pharmacological profiles of SC-hCMs were compared to rabbi...

Aim. To compare the pharmacokinetics and pharmacodynamics of herbal ointment Liu-He-Dan (LHD) and micron LHD (MLHD) in rats with acute pancreatitis (AP). Methods. Twenty rats were allocated into normal, AP, LHD, and MLHD groups. LHD or MLHD was applied on rats' abdomens. Plasma levels of emodin, rhein, aloe emodin, physcion, and chrysophanol were determined by high performance liquid chromatogr...

Com o objetivo de avaliar os efeitos do uso aditivo em ensilagem sorgo, foi conduzindo um experimento que se analisou parâmetros produtivos, fermentativos e a qualidade nutricional das silagens. O delineamento experimental inteiramente casualizado, sendo testados diferentes níveis inclusão enzimático Rovabio® pó, constituindo seguintes tratamentos: 1) Sorgo sem enzimas (controle), 2) + 100 g/to...