Rotavirus infections are a common cause of gastroenteritis in infants and young children worldwide. Although rotavirus gastroenteritis is usually self-limiting in healthy infants, approximately 33% of cases of severe diarrhoea require hospitalization (1). Small intestinal epithelium dysfunction during rotavirus gastroenteritis is well-documented. Enteric Gram-negative bacteraemia as a complicat...

BACKGROUND Rotavirus is the most common cause of gastroenteritis in young children worldwide. The aim of the study was to assess the health outcomes and the economic impact of a universal rotavirus vaccination programme with RotaTeq, the pentavalent rotavirus vaccine, versus no vaccination programme in Spain. METHODS A birth cohort was followed up to the age of 5 using a cohort model. Epidemi...

INTRODUCTION Rotavirus is the main etiological cause of intestinal infections in children. Voluntary rotavirus vaccines were included in the Polish vaccination schedule in 2007. The aim of this study was to assess the effectiveness of a completed rotavirus vaccination course in preventing acute gastroenteritis in Polish infants during their first five years of life. MATERIAL AND METHODS This ...

A human stool filtrate containing rotavirus which was administered orally to gnotobiotic lambs caused diarrhea, virus excretion, development of antibodies to rotavirus, and pathological changes in the villi of the small intestine. Thus, lambs may serve as experimental animals for the study of human rotavirus infections. This model system was used to study passive protection. Human immunoglobuli...

Rotavirus is one of the most common causes of childhood diarrheal disease and deaths in sub-Saharan Africa. This article reviews community- and hospital-based surveillance of rotavirus disease in Bissau, Guinea-Bissau, West Africa. Here, rotavirus infections exhibit a seasonal pattern, with annual epidemics occurring during the relatively dry and cooler months, from January to April, and few ca...

OBJECTIVE To estimate the burden of rotavirus-associated gastroenteritis in India. METHODS Hospital based surveillance network was established, with clinical evaluation and laboratory testing for rotavirus among children aged below 5 years hospitalized with acute gastroenteritis. RESULTS Between September 2012 and December 2014, stool samples from 10207 children were tested and rotavirus wa...

INTRODUCTION Diarrheal diseases are among the most frequent causes of morbidity and mortality in children worldwide, especially in resource-poor areas. This case-control study assessed the associations between gastrointestinal infections and diarrhea in children from rural Ghana. METHODS Stool samples were collected from 548 children with diarrhea and from 686 without gastrointestinal symptom...