BACKGROUND N-acetylcysteine (NAC) has been indicated against experimental seizures, but with relatively inconclusive results. This study was undertaken to evaluate whether NAC exerts a dose-dependent anticonvulsant effect and to determine NAC safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses. METHODS Following intraperitoneal (i.p.) administration of ...

BACKGROUND There is evidence supporting the antinociceptive effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in various models of neuropathic pain as well as inflammatory somatic pain. Data are lacking on the antinociceptive potential of these drugs against visceral pain. In this study, we examined and compared the effects of carbamazepine, oxcarbazepine, gabapentin, and topi...

Understanding sex differences in motor abilities is important for understanding motor development in children as well as many disease phenotypes. However, whether there are biologically based differences in motor abilities of both human children and mice is still in debate. There are sex differences in the cerebellum of juvenile mice which suggests that sex differences in motor coordination are...

introduction: the dorsal striatum plays an important role in the control of motor activity and learning processes within the basal ganglia circuitry. furthermore, recent works have suggested functional differentiation between subregions of the dorsal striatum methods: the present study examined the effects of bilateral electrolytic lesions of the dorsomedial striatum on motor behavior and learn...

The effect of a new conjugate hydroxybenzoic acid with glycine on sensory-motor and cognitive impairments in experimental animals chronic cerebrovascular insufficiency (CCI) was studied. CCI modeled rats by stenosis thelumen the carotid arteries 60 %. 40 days after operation, groups were formed test compound administered for 14 days. Citicoline used as reference drug, saline placebo. After trea...

The phospholipid complex of the obtained aqueous fraction (AF) was prepared with Phospholipon 90H. The size of nanophytosomes was determined by dynamic light scattering. HPTLC fingerprinting of the AF was also performed. PTZ and ICES models were used to evaluate the anticonvulsant activity while Rotarod test, Elevated Plus maze test, and Forced swimming test were used to evaluate other neuropha...

Methanolic and ethyl acetate extract of A. galanga showed significant central nervous system (CNS) stimulant activity in mice using actophotometer and rotarod test. CNS stimulation at a dose of 500 mg/kg was comparable with standard drugs caffeine and amphetamine derivative modalart. The extracts did not shown any depressant effect in forced swim or tail suspension tests. It can be concluded th...

Growth hormone (GH) and melatonin are two hormones with quite different physiological effects. Curiously, their secretion shows parallel and severe age-related reductions. This has promoted many reports for studying the therapeutic supplementation of both hormones in an attempt to avoid or delay the physical, physiological, and psychological decay observed in aged humans and in experimental ani...