In this study, we identify Prospero-related homeobox 1 (Prox1) as a novel co-repressor of the retinoic acid-related orphan receptors, RORα and RORγ. Prox1 interacts directly with RORγ and RORα and negatively regulates their transcriptional activity. The AF2 domain of RORs is essential for the interaction, whereas Prox1 interacts with RORs through either its 28 amino acids N-terminal region or i...

Wnts make up a large family of extracellular signaling molecules that play crucial roles in development and disease. A subset of noncanonical Wnts signal independently of the transcription factor β-catenin by a mechanism that regulates key morphogenetic movements during embryogenesis. The best characterized noncanonical Wnt, Wnt5a, has been suggested to signal via a variety of different recepto...

OBJECTIVE To synthesise evidence on the average bias and heterogeneity associated with reported methodological features of randomized trials. DESIGN Systematic review of meta-epidemiological studies. METHODS We retrieved eligible studies included in a recent AHRQ-EPC review on this topic (latest search September 2012), and searched Ovid MEDLINE and Ovid EMBASE for studies indexed from Jan 2...

Innate lymphoid cells (ILC) combine innate and adaptive immune functions and are part of the first line of defense against mucosal infections. ILC are set apart from adaptive lymphocytes by their independence on RAG genes and the resulting absence of specific antigen receptors. In this review, we will discuss the biology and function of intestinal ILC that express the nuclear hormone receptor R...

The circadian clock mechanism in mammals involves two interlocking transcriptional feedback loops. Rev-erb alpha, through its role as a transcriptional repressor, was thought to be the primary determinant of the feedback loop that regulates Bmal1 transcription. Results reported by Sato et al. in this issue of Neuron now show that the transactivator Rora acts coordinately with Rev-erb alpha and ...

IL-17–producing CD4 + Th17 cells, CD8 + Tc17 cells, and gd T cells play critical roles in the pathogenesis of autoimmune psoriasis. RORgt is required for the differentiation of Th17 cells and expression of IL-17. In this article, we describe a novel, potent, and selective RORgt inverse agonist (TMP778), and its inactive diastereomer (TMP776). This chemistry, for the first time to our knowledge,...

Password-based Authenticated Key-Exchange (PAKE) protocols allow users, who need only to share a password, to compute a high-entropy shared session key despite passwords being taken from a dictionary. Security models for PAKE protocols aim to capture the desired security properties that such protocols must satisfy when executed in the presence of an active adversary. They are usually classified...

In this paper, we present a simple method to estimate the realisation bit error rate (RBER) of a multiband orthogonal frequency division multiplexing (OFDM)-based ultra-wide band (UWB) system. Under time-varying channels, error event based BER estimation of convolutionally encoded systems requires the knowledge of error events in the Viterbi decoding. In this work, we show that the upper-bound ...

Background: Vitamin D insufficiency and deficiency can be associated with adverse effects on fetus and pregnancy outcomes. This study aimed at evaluating the effect of 1,25VitD3 on specific transcription factor and markers of Tregs and Th17 cells in the PBMCs of women with URPL as a case group and the PBMCs of healthy women as a control group. Methods: Samples from 20 non-pregnant patients with...