[1] The role of bedrock fractures and rock mass strength is often considered a primary influence on the efficiency of surface processes and the morphology of landscapes. Quantifying bedrock characteristics at hillslope scales, however, has proven difficult. Here, we present a new field‐based method for quantifying the depth and apparent density of bedrock fractures within the shallow subsurface...

Rock slope stability depends very much on the strength features of the rock and the geometrical and strength characteristics of the discontinuities (e.g., roughness, wall strength and persistence). Since a rock mass is not a continuum, its behavior is dominated by such discontinuities as faults, joints and bedding planes. Also, Rock slope instability is a major hazard for human activities and o...

The initiation, propagation, coalescence and failure mode of brittle jointed rock mass influenced by fissure water pressure have always been studied as a hot issue in the society of rock mechanics and engineering. In order to analyze the damage evolution process of jointed rock mass under fracture water pressure, a novel numerical model on the basis of secondary development in fast Lagrangian a...

The excavation damaged zone (EDZ) can be defined as a rock zone where the rock properties and conditions have been changed due to the processes related to an excavation. This zone affects the behavior of rock mass surrounding the construction that reduces the stability and safety factor and increase probability of failure of the structure. In this paper, a methodology was examined for computing...

rock slope stability depends very much on the strength features of the rock and the geometrical and strength characteristics of the discontinuities (e.g., roughness, wall strength and persistence). since a rock mass is not a continuum, its behavior is dominated by such discontinuities as faults, joints and bedding planes. also, rock slope instability is a major hazard for human activities and o...

Regenerative failure in the CNS largely depends on pronounced growth inhibitory signaling and reduced cellular survival after a lesion stimulus. One key mediator of growth inhibitory signaling is Rho-associated kinase (ROCK), which has been shown to modulate growth cone stability by regulation of actin dynamics. Recently, there is accumulating evidence the ROCK also plays a deleterious role for...

BACKGROUND Cardiac metabolism is critical for the functioning of the heart, and disturbance in this homeostasis is likely to influence cardiac disorders or cardiomyopathy. Our laboratory has previously shown that SNRK (sucrose nonfermenting related kinase) enzyme, which belongs to the AMPK (adenosine monophosphate-activated kinase) family, was essential for cardiac metabolism in mammals. Snrk g...

Intrahepatic cholestasis represents a frequent manifestation of drug-induced liver injury; however, the mechanisms underlying such injuries are poorly understood. In this study of human HepaRG and primary hepatocytes, we found that bile canaliculi (BC) underwent spontaneous contractions, which are essential for bile acid (BA) efflux and require alternations in myosin light chain (MLC2) phosphor...

Some of the geotechnical parameters used in the analysis may not be accurately measured directly from laboratory tests due to effects of sample disturbance and errors of tests. The back analysis or the observational method are thus often applied to determine the representative and/or dominant strength parameters based on field observations in practice. Based on the Hoek-Brown failure criterion,...