The paper presents methods for assessing economic, resource and environmental efficiency of energy supply systems and ways of its improvement, the main of which are the development of cogeneration and renewable energy sources (RES). The problem of allocating fuel and financial costs in the case of the combined production is solved. The methods allow determining specific indicators of supplied p...

Rho-associated kinase (ROCK) signaling plays a fundamental role in regulating cell morphology, adhesion, and motility. Aberrant expression of ROCK is related to tumor metastases and poor clinical outcome. Here, we show that ROCK expression is increased in metastatic human mammary tumors and breast cancer cell lines compared with nonmetastatic tumors and cell lines. Overexpression of ROCK confer...

The subject of this thesis forms part of a research program dealing with fractured rock masses being undertaken by the "Centre de Géologie de l'Ingénieur (CGI)" from the "Ecole Nationale Supérieure des Mines de Paris (ENSMP)" and the "Ecole Nationale des Ponts et Chaussées (ENPC)". In fractured rock masses, it is very difficult to undertake engineering works without analysing, beforehand, the f...

The prediction of rock mass behavior is an important task in many engineering projects, as the behavior of rock masses can be controlled by the presence of discontinuities. Being able to map the structure of a rock mass is crucial to understanding its potential behavior. This understanding can positively impact the safety and efficiency of an engineering project. In this research, rock masses w...

In underground tunnels or caverns, time-dependent deformation or failure of rock mass, such as extending cracks, gradual rock falls, etc., are a costly irritant and a major safety concern if the time-dependent damage of surrounding rock is serious. To understand the damage evolution of rock mass in underground engineering, an in situ experimental testing was carried out in a large belowground t...

Drilling and blasting have numerous applications in the civil and mining engineering. Due to the two major components of rock masses, namely the intact rock matrix and the discontinuities, their behavior is a complicated process to be analyzed. The purpose of this work is to investigate the effects of the geomechanical and geometrical parameters of rock and discontinuities on the rock mass blas...