RK-1409B, a new inhibitor of protein kinase C, was isolated from the culture broth of Streptomyces platensis subsp. malvinus RK-1409. The structure was elucidated on the basis of spectroscopic analyses. RK-1409B inhibited protein kinase C in vitro and the morphological change of a human chronic leukemia cell line, K-562, induced by phorbol 12,13-dibutyrate with IC50 value of 0.4 microM.

For a compact surface Σ (orientable or not, and with boundary or not) we show that the fixed subgroup, FixB, of any family B of endomorphisms of π1(Σ) is compressed in π1(Σ), i.e., rk(FixB) 6 rk(H) for any subgroup FixB 6 H 6 π1(Σ). On the way, we give a partial positive solution to the inertia conjecture, both for free and for surface groups. We also investigate direct products, G, of finitely...

The Runge-Kutta (RK)-Butcher algorithm is used to study the timevarying singular bilinear systems with the exact solutions. The results (discrete solutions) obtained using the Haar wavelets, Single-Term Walsh series (STWS) and RK-Butcher algorithms are compared with the exact solutions of the time-varying singular bilinear systems. It is found that the solution obtained using the RK-Butcher alg...

OBJECTIVES To study the effects of radial keratotomy (RK) and photorefractive keratectomy (PRK) on contrast sensitivity and glare disability using 4 different devices, and to correlate subjective complaints with obj ective scores of visual performance. METHODS Preoperative contrast sensitivity for 30 eyes undergoing RK and 30 eyes undergoing PRK was compared with contrast sensitivity at 1, 3,...

A new composite Runge–Kutta (RK) method is proposed for semilinear partial differential equations such as Korteweg–de Vries, nonlinear Schrödinger, Kadomtsev– Petviashvili (KP), Kuramoto–Sivashinsky (KS), Cahn–Hilliard, and others having high-order derivatives in the linear term. The method uses Fourier collocation and the classical fourth-order RK method, except for the stiff linear modes, whi...

A new composite Runge–Kutta (RK) method is proposed for semilinear partial differential equations such as Korteweg–de Vries, nonlinear Schrödinger, Kadomtsev– Petviashvili (KP), Kuramoto–Sivashinsky (KS), Cahn–Hilliard, and others having high-order derivatives in the linear term. The method uses Fourier collocation and the classical fourth-order RK method, except for the stiff linear modes, whi...

Pseudorabies virus (PRV) propagated in rabbit kidney-derived RK-13 cells (PRV-RK) was neutralized by serum obtained from specific pathogen-free pigs through the activation of complement. The virus-neutralizing activity of swine serum was lost after treatment with ethylene glycol-bis-aminoethylether-N,N,N',N'-tetraacetic acid (EGTA) or ethylenediaminetetraacetic acid (EDTA). Anti-C1q and anti-Ig...

We look at relationships among the lengths of diagonals in the regular polygon. Specifically, we derive formulas for all diagonals in terms of the shortest diagonals and other formulas in terms of the next-to-shortest diagonals, assuming unit side length. These formulas are independent of the number of sides of the regular polygon. We also show that the formulas in terms of the shortest diagona...

The Epstein-Barr virus (EBV) BamHI A mRNAs were originally identified in cDNA libraries from nasopharyngeal carcinoma, where they are expressed at high levels. The RNAs are differentially spliced to form several open reading frames and also contain the BARF0 open reading frame at the 3' end. One cDNA, RK-BARF0, included a potential endoplasmic reticulum-targeting signal peptide sequence. The RK...

Let {ak}, k = 1, . . . , N be a family of matrices of sizes rk × rk−1. For positive integers i, j, i > j define the operation aij as follows: a × ij = ai−1 · · ·aj+1 for i > j + 1, aj+1,j = Irj . Let {bk}, k = 1, . . . , N be a family of matrices of sizes rk−1 × rk. For positive integers i, j, j > i define the operation bij as follows: b × ij = bi+1 · · · bj−1 for j > i+ 1, bi,i+1 = Iri . It is...