نتایج جستجو برای: ritanserin

تعداد نتایج: 124  

Journal: :Neuroscience research 1997
J L Góngora-Alfaro S Hernández-López J Flores-Hernández E Galarraga

Unitary extracellular recordings were made in in vitro rat brain slices to explore the effects of serotoninergic analogues on the spontaneous activity of substantia nigra reticulata (SNr) neurons. Most SNr neurons exhibited regular spontaneous firing (23.4 +/- 8.9 Hz, mean +/- S.E.M., n = 30) similar to that found in vivo. The most reproducible effect of serotonin (5-HT) was an increase in firi...

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Journal: :Japanese Heart Journal 1987

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Journal: :Biological & pharmaceutical bulletin 2001
M Rashid M Watanabe M Nakazawa T Nagatomo

The object of this study was to investigate the binding affinity of a newly synthesized 5-HT2 antagonist, (N-[2-[4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino]ethyl]-1-formyl-4-piperidinecarboxamide monohydrochloride monohydrate) (AT-1015), in the rabbit platelet membrane using [3H]-ketanserin by radioligand binding assay method and to compare the results with other selective 5-HT2 antago...

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Journal: :Cell 2011
Miguel Fribourg José L. Moreno Terrell Holloway Davide Provasi Lia Baki Rahul Mahajan Gyu Park Scott K. Adney Candice Hatcher José M. Eltit Jeffrey D. Ruta Laura Albizu Zheng Li Adrienne Umali Jihyun Shim Alexandre Fabiato Alexander D. MacKerell Vladimir Brezina Stuart C. Sealfon Marta Filizola Javier González-Maeso Diomedes E. Logothetis

Atypical antipsychotic drugs, such as clozapine and risperidone, have a high affinity for the serotonin 5-HT(2A) G protein-coupled receptor (GPCR), the 2AR, which signals via a G(q) heterotrimeric G protein. The closely related non-antipsychotic drugs, such as ritanserin and methysergide, also block 2AR function, but they lack comparable neuropsychological effects. Why some but not all 2AR inhi...

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Journal: :Hiroshima journal of medical sciences 1989
T Kato S Yamawaki

Stereotaxic microinjection of veratrine (50 micrograms in 1 microliter of saline) into the preoptic anterior hypothalamus of rats which were intraperitoneally pretreated with haloperidol (1 mg/kg), significantly elevated body temperature (1.4 degrees C above normal body temperature) and produced abnormal behaviors. This microinjection also facilitated turnover of dopamine and serotonin in the r...

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Journal: :Journal of neurophysiology 1998
E Bracci M Beato A Nistri

Bath-application of increasing concentrations of extracellular K+ elicited alternating motor patterns recorded from pairs of various lumbar ventral roots of the neonatal rat (0-2 days old) spinal cord in vitro. The threshold concentration of K+ for this effect was 7.9 +/- 0.8 mM (mean +/- SD). The suprathreshold concentration range useful to evoke persistent motor patterns (lasting >/=10 min) w...

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Journal: :The Journal of pharmacology and experimental therapeutics 2003
Craig R Rush William W Stoops Lon R Hays Paul E A Glaser Lon S Hays

Studies conducted with nonhuman laboratory animals have consistently shown that atypical antipsychotics that are mixed dopamine and serotonin antagonists attenuate the discriminative-stimulus effects of amphetamine. In the present experiment, eight healthy humans learned to discriminate 15 mg of oral d-amphetamine. After acquiring the discrimination (i.e., > or = 80% correct responding on four ...

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Journal: :The Journal of clinical investigation 1994
P A Taheri H L Lippton S D Force E W Franklin A L Hyman L M Flint J J Ferrara

Ultrasonic probes were placed around dog femoral arteries to record blood flow. Hind paw scalding with boiling water (5 s) caused a marked increase in ipsilateral femoral blood flow that persisted for the 2-h observation period. Contralateral femoral blood flow and systemic and pulmonary vascular resistances were unchanged. Compared to scald only animals, methysergide pretreatment diminished an...

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Journal: :Fundamental & clinical pharmacology 2014
Francisca Cléa Florenço de Sousa Iris Cristina Maia Oliveira Maria Izabel Gomes Silva Carla Thiciane Vasconcelos de Melo Vívian Romero Santiago Raquell de Castro Chaves Mariana Lima Fernandes Stanley Juan Chaves Gutierrez Silvânia Maria Mendes Vasconcelos Danielle Silveira Macêdo José Maria Barbosa Filho

In past studies conducted by our group, riparin I (rip I) isolated from the green fruit of Aniba riparia presented antianxiety effects in mice, while its analogs rip II and III showed anxiolytic and antidepressant-like actions. This time around, we investigated a possible antidepressant activity of rip I using the forced swimming test (FST) and tail suspension test (TST) as predictive tests for...

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Journal: :The Journal of pharmacology and experimental therapeutics 2000
W L Bacon S G Beck

The 5-hydroxytryptamine(7) (5-HT(7)) receptor was originally defined by molecular biology techniques. The 5-HT(7) receptor protein and mRNA are found in brain areas, such as the CA3 subfield of the hippocampus, that are involved in various neuropsychiatric disease states. No functional response has previously been attributed to activation of the 5-HT(7) receptor in any of these brain areas. Cal...

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