Epithelial tissues in which carcinomas develop often contain systemically derived T cell receptor (TCR)alphabeta+ cells and resident intraepithelial lymphocytes that are commonly enriched in TCRgammadelta+ cells. Recent studies have demonstrated that gammadelta cells protect the host against chemically induced cutaneous malignancy, but the role of alphabeta T cells has been enigmatic, with both...

Antigen recognition by T lymphocytes is mediated by cell-surface glycoproteins known as T-cell antigen receptors (TCRs). These are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. In contrast to alphabeta TCRs, which recognize antigen only as peptide fragments bound to molecules of the major histocompatibility complex (MHC), gammadel...

Conventional alphabeta T cell precursors undergo positive selection in the thymic cortex. When this is successful, they migrate to the medulla and are exposed to tissue-specific antigens (TSA) for purposes of central tolerance, and they undergo maturation to become functionally responsive T cells. It is commonly understood that thymocytes spend up to 2 wk in the medulla undergoing these final m...

Mouse CD1.1 is an MHC class I-like, non-MHC-encoded, surface glycoprotein that can be recognized by T cells, in particular NK1.1+ T cells, a subset of alphabeta T cells with semiinvariant TCRs that promptly releases potent cytokines such as IL-4 and IFN-gamma upon stimulation. To gain insight into the function of CD1.1, a panel of nine mAbs was generated and used to biochemically characterize a...

How structural adaptability exists alongside HLA-A2 bias in the human alphabeta TCR repertoire" (2016).

We study interaction-induced quantum correction deltasigma(alphabeta) to the conductivity tensor of electrons in two dimensions for arbitrary Ttau, where T is the temperature and tau the transport mean free time. A general formula is derived, expressing deltasigma(alphabeta) in terms of classical propagators ("ballistic diffusons"). The formalism is used to calculate the interaction contributio...

in this paper, we study some ring theoretic properties of the amalgamated duplication ring $rbowtie i$ of a commutative noetherian ring $r$ along an ideal $i$ of $r$ which was introduced by d'anna and fontana. indeed, it is determined that when $rbowtie i$ satisfies serre's conditions $(r_n)$ and $(s_n)$, and when is a normal ring, a generalized cohen-macaulay ring and finally a filter ring.

in this paper, we introduce a class of $j$-quasipolar rings. let $r$ be a ring with identity. an element $a$ of a ring $r$ is called {it weakly $j$-quasipolar} if there exists $p^2 = pin comm^2(a)$ such that $a + p$ or $a-p$ are contained in $j(r)$ and the ring $r$ is called {it weakly $j$-quasipolar} if every element of $r$ is weakly $j$-quasipolar. we give many characterizations and investiga...

in this paper, we investigate various kinds of extensions of twin-good rings. moreover, we prove that every element of an abelian neat ring r is twin-good if and only if r has no factor ring isomorphic to z2  or z3. the main result of [24] states some conditions that any right self-injective ring r is twin-good. we extend this result to any regular baer ring r by proving that every element of a...