OBJECTIVE To compare the frequency and severity of post dural puncture headache in obstetric patients using 25G Quincke, 27G Quincke and 27G Whitacre spinal needles. DESIGN Comparative, randomized, double-blind, interventional study. PLACE AND DURATION OF STUDY Liaquat University Hospital Hyderabad from October 2005 to December 2006. PATIENTS AND METHODS 480 ASA I-II full term pregnant wo...

Purpose: A recent change in pars plan vitrectomy (PPV) has been the advent of smaller gauge “sutureless” instrumentation. Sutureless systems are designed to create selfsealing and leak free sclerotomies. This study’s purpose was to evaluate sutureless 23 gauge (23G) wound integrity via ultrasonographic, photographic, and tonographic techniques using a retrospective case series analysis. Method:...

BACKGROUND Many patients with autoimmune hemolytic anemia (AIHA) do not respond to standard therapy and/or may develop severe complications which can be of fatal outcome. There is some evidence that erythropoiesis-stimulating agents (ESAs) may be helpful in the management of such patients. METHODS We describe the effect of ESAs in 12 new patients with therapy-refractory AIHA (7 of warm type a...

The hallmark of the autoimmune hemolytic anemias (AIHAs) and paroxysmal nocturnal hemoglobinuria (PNH) is shortened red blood cell survival. Although AIHA and PNH share the critical feature of shortened red cell survival, the mechanisms underlying this characteristic differ significantly between the two diseases. In the case of AIHA, autoantibodies directed against the patient’s own red blood c...

BACKGROUND Autoimmune neutropenia (AIN) can occur in association with autoimmune hemolytic anemia (AIHA) and/or immune thrombocytopenic purpura (ITP), although these associations have not been studied in detail. METHODS AND RESULTS Twenty cases of AIN were found in a group of 55 adults with unexplained neutropenia over a five-year period. Eight subjects with AIN had an associated AIHA and/or ...

BACKGROUND The therapeutic efficacy of red blood cell (RBC) transfusions in patients with autoimmune hemolytic anemia (AIHA) is highly debated because of speculations on the increased risk of transfusion reactions; yet it is a suggested adjuvant therapy in anemic patients with life-threatening hypoxemia. In this study, we evaluated the safety and efficacy of RBC transfusions in AIHA patients. ...

Hodgkin's lymphoma accounts for ten percent of all lymphomas. In the United States, there are about 8000 new cases every year. This paper describes a case of lymphocyte-rich Hodgkin's lymphoma (LRHL) manifested by autoimmune hemolytic anemia (AIHA). A 27-year-old Israeli male presented with dizziness associated with one month of low-grade fevers and night sweats; he also complained of persisten...

Aim: Autoimmune hemolytic anemia (AIHA) is characterized by the production of antibodies directed against red blood cells. We aimed to describe clinical presentation, hematologic and biochemical profiles, treatment modalities, underlying diseases outcomes in children suffering from AIHA. 
 Material Method: In a retrospectively manner, we consecutively recrutied 62 (aged 1 month-18 years) w...

Standard treatment for autoimmune hemolytic anemia (AIHA) due to warm antibodies includes combinations of glucocorticoids, immunosuppressive drugs (mainly azathioprine) and splenectomy. Patients who are refractory or intolerant to these therapies constitute an important therapeutic challenge. Rituximab, an anti-CD20 chimeric monoclonal antibody, can effectively deplete B-cells and is commonly u...

Adalimumab is commonly used to treat autoimmune diseases with few reported hematological adverse reactions. We herein describe the case of an 85-year-old Japanese man with plaque psoriasis who developed autoimmune hemolytic anemia (AIHA) after 3 years of adalimumab treatment. The patient suddenly developed hematuria and dyspnea on exertion while receiving adalimumab treatment. Laboratory data s...