Chromosome breakage as a result of replication stress has been hypothesized to be the direct consequence of defective replication fork progression, or "collapsed" replication forks. However, direct and genome-wide evidence that collapsed replication forks give rise to chromosome breakage is still lacking. Previously we showed that a yeast replication checkpoint mutant mec1-1, after transient ex...

It has been observed that the pattern of particle impact breakage in two-dimensional systems is a result of two mechanisms. AMechanism IB accounts for the breakage induced by the stresses that appear in unbroken particles. AMechanism IIB breakage is due to the buckling of the Mechanism I fragments. The purpose of this paper is to try and understand the parameters that govern the magnitude of th...

The transposable Dissociation (Ds) element of maize was first discovered as a site of high-frequency chromosome breakage. Because both Ds-mediated breakage and transposition require the presence of the Activator (Ac) element, it has been suggested that chromosome breakage may be the outcome of an aberrant transposition event. This idea is consistent with the finding that only complex structures...

Objectives: To identify (1) the prevalence of condom breakage, and demographic and sexuality-related differences among young men who have sex with women reporting and not reporting this event; (2) condomspecific behaviours associated with breakage. Methods: Young men (n = 278) attending a clinic for treatment of sexually transmitted infections (STIs) responded to an anonymous questionnaire aide...