Riboflavin transporter 1 (RFVT1) deficiency is an ultrarare metabolic disorder due to autosomal dominant pathogenic variants in SLC52A1. The RFVT1 protein mainly expressed the placenta and intestine. To our knowledge, only five cases of from three families have been reported so far. While newborns infants with SLC52A1 showed a multiple acyl-CoA dehydrogenase deficiency-like presentation, indivi...

Iron (Fe) is an essential mineral that has low solubility in alkaline soils, where its deficiency results in chlorosis. Whether low Fe supply and alkaline pH stress are equivalent is unclear, as they have not been treated as separate variables in molecular physiological studies. Additionally, molecular responses to these stresses have not been studied in leaf and root tissues simultaneously. We...

An increase in liver: body-weight and in hepatic triacylglycerol content, together with changes in the fatty acid profiles of hepatic phospholipids, were observed as a result of moderate riboflavin deficiency in sucking rat pups. Oxygen consumption by hepatic mitochondria, with palmitoyl L-carnitine as substrate, was not significantly impaired. Mitochondria from interscapular brown adipose tiss...

Introduction Riboflavin was originally recognized as a growth factor in 1879 and named vitamin B2 according to the British nomenclature system. It was first isolated from egg whites in 1934 and synthesized in 1935.1,2 Riboflavin fluoresces yellow-orange and gives the yellow-white hue to egg whites and milk. Riboflavin has two active coenzyme forms, riboflavin 5’-phosphate (R5P; flavin mononucle...

The finding of tomacula, focal areas of sausage-shaped hypermyelination in peripheral nerves, is reported for the first time in avian riboflavin deficiency. Day-old, meat-type chickens were fed a riboflavin-deficient diet (1.8 mg/kg) and were killed on postnatal days 6, 11, 16, and 21, while control chickens were fed a conventional diet containing 5.0 mg/kg riboflavin. Tomacula were found in sc...

For the assessment of nutritional riboflavin status in man, several methods have been applied which are, in their basic principles, comparable with the methods for assessing the status of other vitamins. One approach involves the determination of the dietary riboflavin intake by means of food composition tables or by chemical analysis of food samples (Roine & Pekkharinen, 1968; van Schaik, 1968...

In a preceding paper of ours,1 it was reported that a marked decrease of N5,10methylenetetrahydrofolate reductase as well as a considerable decrease of N5 methyltetrahydrofolate transferase activity in the liver was found in riboflavin deficient rats. In the present study, chromatographic analysis followed by microbiologic assay of folate derivatives in the liver was made on rats with or withou...