Studies were undertaken in man and in the rat comparing the effects of rheumatoid factors and immune antiglobulins on red cells sensitized with incomplete antibodies. The interaction of immune antiglobulins with sensitized red cells produced (a) agglutination in vitro and (b) an accelerated sequestration of the sensitized cells in vivo. In contrast, rheumatoid macroglobulins, although capable o...

In order to examine the interactions between isolated rheumatoid factors (RFs) and cell nuclear antigens we have prepared 10 RFs by affinity chromatography against IgG coupled to Sepharose. Of these, seven cross reacted with cell nuclei on indirect immunofluorescence. The nuclear antigen appeared to be DNA histones by indirect immunofluorescence on rat liver, though on immunoblotting the rheuma...

DT. Factors predicting response to treatment in rheumatoid arthritis: the importance of disease duration. Arthritis Rheum 2000;43:22–9. 15 Kroot EJ, van Leeuwen MA, van Rijswijk MH, Prevoo ML et al. No increased mortality in patients with rheumatoid arthritis: up to 10 years of follow up from disease onset. Ann Rheum Dis 2000;59:954–8. 16 Nell VP, Machold KP, Eberl G, Stamm TA et al. Benefit of...

McCormick and Day (1963) reported that rheumatoid factors and 7S ANF co-existing in the same seramayform high molecular weight complexes, and absorption studies have brought forward evidence of an interaction between ANF and rheumatoid factors when present in the same serum (Holborow and Johnson, 1965). However, ANF in rheumatoid arthritis have mostly been found in low frequency and chiefly in ...