Infections and rheumatic diseases have shared a close relationship since time immemorial. Some are direct consequence of infections while others been associated with certain microbes without an established causal link. The above is becoming more complex due to rapid advances in therapeutics, also because factors such as climate change worldwide travel. This brief review the major facets this de...

Institute for Regional Health Research, University of Southern Denmark, Hospital of Southern Jutland, Aabenraa and King Christian X’s Hospital for Rheumatic Diseases, Graasten, Denmark Outpatient Department, King Christian X’s Hospital for Rheumatic Diseases, Graasten, Denmark Institute for Regional Health Research, University of Southern Denmark and King Christian X’s Hospital for Rheumatic Di...

This study aimed to evaluate the diagnostic utilities of the automated connective tissues disease screening assay, CTD screen, in patients with systemic rheumatic diseases. A total of 1093 serum samples were assayed using CTD screen and indirect immunofluorescent (IIF) methods. Among them, 162 were diagnosed with systemic rheumatic disease, including rheumatoid arthritis (RA), systemic lupus er...

With enormous speed novel data are emerging about regulating the expression of the genetically encoded information [1]. This highly complex regulatory network called epigenetics includes acetylation, methylation, phosphorylation, sumoylation and non-coding RNAs (ncRNA), such as miRNA and lncRNAs. Our laboratory is addressing over the past decade inflammatory rheumatic diseases [2], like rheumat...

The aetiology of rheumatoid diseases is unclear but may be multifactorial, the result of complex interactions between environmental, neuroendocrinological, and genetic factors. Whilst several viruses (for example cytomegalovirus, Epstein-Barr virus, rubella virus and parvovirus B19 are associated with self limiting arthritic episodes, retroviruses have been suggested as aetiological agents of r...

There are many studies which demonstrate a higher risk for malignancy in patients with rheumatic diseases. There have been a number of possible explanations for the differences in the risk of certain malignancies in patients with rheumatic disease, compared with general population, but a clear mechanism is difficult to identify.Rheumatoid syndromes may be associated with malignancy as paraneopl...

OBJECTIVE: To present an updated review concerning the most prevalent diseases with musculoskeletal signs and symptoms that make adolescents seek medical care, giving special emphasis to rheumatic diseases. Our aim is to offer physicians and health care providers the possibility of distinct differential diagnoses, thus allowing them to establish a therapeutic approach and, if necessary, refer t...

Although B cells and T cells are indistinguishable from each other on a blood smear, their phenotypes are clearly different. Differences in membrane immunoglobulin expression were noted in early studies. Subsequently, the development of monoclonal antibodies led to the identification of cluster of differentiation (CD) molecules at the cell surface. The CD pattern can be used to characterize the...

Radiosynovectomy is a safe and repeatable treatment method of chronic synovitis with synovial overgrowth and refractory chronic or acute inflammatory joint effusion. It consist in the intraarticular administration of a radioactive isotope in the form of a colloid causing the extinguishing of active synovitis. The radiocolloid causes permanent irradiation of the synovium with beta ray electron b...